Dược Động Học :
▧ Absorption :
Ophthalmic use of emedastine usually does not produce measurable plasma concentrations.
▧ Metabolism :
Two primary metabolites, 5-hydroxyemedastine and 6-hydroxyemedastine, are excreted in the urine as both free and conjugated forms. The 5'-oxoanalogs of 5-hydroxyemedastine and 6-hydroxy-emedastine and the N-oxide are also formed as minor metabolites.
▧ Route of Elimination :
Approximately 44% of the oral dose is recovered in the urine over 24 hours with only 3.6% of the dose excreted as parent drug. Two primary metabolites, 5- and 6-hydroxyemedastine, are excreted in the urine as both free and conjugated forms.
▧ Half Life :
The elimination half-life of oral emedastine in plasma is 3-4 hours.