Tìm theo
Efalizumab
Các tên gọi khác (4 ) :
  • anti alphaL integrin
  • antiCD11 alpha
  • hu1124
  • Raptiva
Thuốc giảm miễn dịch
Thuốc Gốc
Biotech
CAS: 214745-43-4
ATC: L04AA21
ĐG : Genentech Inc. , http://www.gene.com
Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Độ tan chảy
61 °C (FAB fragment), 71 °C (whole mAb)
Dược Lực Học : Lymphocyte activation and trafficking to skin play a role in the pathophysiology of chronic plaque psoriasis. In psoriatic skin, ICAM-1 cell surface expression is upregulated on endothelium and keratinocytes. Raptiva inhibits the binding of LFA-1 to the intercellular adhesion molecule-1 (ICAM-1), thereby inhibiting the adhesion of leukocytes to other cell types.
Cơ Chế Tác Dụng : Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. Efalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes. As a result efalizumab decreases cell surface expression of CD11a.
Dược Động Học :
▧ Absorption :
Average efalizumab bioavailability following subcutaneous administration was estimated at 30 to 50%.
▧ Half Life :
5 days
Chỉ Định : For the treatment of adult patients with moderate to severe chronic plaque psoriasis, who are candidates for phototherapy or systemic therapy.
Tương Tác Thuốc :
  • Ergonovine The antiretroviral agent may increase the ergot derivative
  • Rilonacept results in increased immunosuppressive effects; increases the risk of infection.
  • Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Liều Lượng & Cách Dùng : Powder, for solution - Subcutaneous
Dữ Kiện Thương Mại
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Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00095
PharmGKB
http://www.pharmgkb.org/drug/PA164748817
Wikipedia
http://en.wikipedia.org/wiki/Efalizumab
RxList
http://www.rxlist.com/cgi/generic3/raptiva.htm
Drugs.com
http://www.drugs.com/cdi/efalizumab.html
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