Tìm theo
Edetic Acid
Các tên gọi khác (14 ) :
  • (Ethylenedinitrilo)tetraacetic acid, ion(4-)
  • {[-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetic acid
  • 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate
  • Acide edetique
  • Acide ethylenediaminetetracetique
  • Acido edetico
  • Acidum edeticum
  • Edetic acid
  • EDTA
  • EDTA, ion(4-)
  • Ethylenediaminetetraacetate
  • Ethylenediaminetetraacetic acid
  • H4Edta
  • N,N'-1,2-Ethane diylbis-(N-(carboxymethyl)glycine)
Thuốc tác dụng lên quá trình đông máu
Thuốc Gốc
Small Molecule
CAS: 62-33-9
ATC: V03AB03
ĐG : Bioniche Pharma , http://www.bionichepharmausa.com
CTHH: C10H16N2O8
PTK: 292.2426
A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H16N2O8
Phân tử khối
292.2426
Monoisotopic mass
292.090665498
InChI
InChI=1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)
InChI Key
InChIKey=KCXVZYZYPLLWCC-UHFFFAOYSA-N
IUPAC Name
2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetic acid
Traditional IUPAC Name
edetic acid
SMILES
OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O
Độ tan chảy
237 °C
Độ hòa tan
1000000 mg/L at 25 °C
logP
-2.6
logS
-1.5
pKa (strongest acidic)
1.49
pKa (Strongest Basic)
8.13
PSA
155.68 Å2
Refractivity
62.35 m3·mol-1
Polarizability
25.64 Å3
Rotatable Bond Count
11
H Bond Acceptor Count
10
H Bond Donor Count
4
Physiological Charge
-3
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Edetate calcium is a heavy metal chelating agent. The calcium in edetate calcium can be displaced by divalent or trivalent metals to form a stable water soluble complex that can be excreted in the urine. In theory, 1 g of edetate calcium can theoretically bind 620 mg of lead, but in reality only about 5 mg per gram is actually excreted into the urine in lead poisoned patients. In addition to chelating lead, edetate calcium also chelates and eliminates zinc from the body. Edetate calcium also binds cadmium, copper, iron and manganese, but to a much lesser extent than either lead or zinc. Edetate calcium is relatively ineffective for use in treating mercury, gold or arsenic poisoning.
Cơ Chế Tác Dụng : A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive. [PubChem] The pharmacologic effects of edetate calcium disodium are due to the formation of chelates with divalent and trivalent metals. A stable chelate will form with any metal that has the ability to displace calcium from the molecule, a feature shared by lead, zinc, cadmium, manganese, iron and mercury. The amounts of manganese and iron metabolized are not significant. Copper is not mobilized and mercury is unavailable for chelation because it is too tightly bound to body ligands or it is stored in inaccessible body compartments. The excretion of calcium by the body is not increased following intravenous administration of edetate calcium disodium, but the excretion of zinc is considerably increased.
Dược Động Học :
▧ Absorption :
Poorly absorbed from the gastrointestinal tract. Well absorbed following intramuscular injection.
▧ Metabolism :
Almost none of the compound is metabolized.
▧ Route of Elimination :
It is excreted primarily by the kidney, with about 50% excreted in one hour and over 95% within 24 hours.2 Almost none of the compound is metabolized.
▧ Half Life :
The half life of edetate calcium disodium is 20 to 60 minutes.
Độc Tính : Inadvertent administration of 5 times the recommended dose, infused intravenously over a 24 hour period, to an asymptomatic 16 month old patient with a blood lead content of 56 mcg/dl did not cause any ill effects. Edetate calcium disodium can aggravate the symptoms of severe lead poisoning, therefore, most toxic effects (cerebral edema, renal tubular necrosis) appear to be associated with lead poisoning. Because of cerebral edema, a therapeutic dose may be lethal to an adult or a pediatric patient with lead encephalopathy. Higher dosage of edetate calcium disodium may produce a more severe zinc deficiency.
Chỉ Định : For the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults.
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Injection, solution - Intramuscular
Injection, solution - Intravenous drip
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Pharmex
    Sản phẩm biệt dược : Cheladrate
  • Công ty : O'Neal, Jones
    Sản phẩm biệt dược : Diso-Tate
  • Công ty : Bersworth
    Sản phẩm biệt dược : Endrate
  • Công ty : United
    Sản phẩm biệt dược : Uni Wash
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00974
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6049
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508301
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00571
ChemSpider
http://www.chemspider.com/Chemical-Structure.5826.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0089-0510-06
PharmGKB
http://www.pharmgkb.org/drug/PA449439
Wikipedia
http://en.wikipedia.org/wiki/EDTA
RxList
http://www.rxlist.com/cgi/generic2/canaversenate.htm
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