Tìm theo
Econazole
Các tên gọi khác (4 ) :
  • (+-)-Econazole
  • 1-(2,4-Dichloro-beta-((P-chlorobenzyl)oxy)phenethyl)imidazole
  • Econazole
  • Econazole Nitrate
Khoáng chất và Vitamin
Thuốc Gốc
Small Molecule
CAS: 27220-47-9
ATC: D01AC03, G01AF05
ĐG : Dispensing Solutions , http://www.drxdispensing.com
CTHH: C18H15Cl3N2O
PTK: 381.684
A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H15Cl3N2O
Phân tử khối
381.684
Monoisotopic mass
380.024996233
InChI
InChI=1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
InChI Key
InChIKey=LEZWWPYKPKIXLL-UHFFFAOYSA-N
IUPAC Name
1-{2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
Traditional IUPAC Name
(+-)-econazole
SMILES
ClC1=CC=C(COC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=C1
Độ tan chảy
162
Độ hòa tan
1.48e-03 g/l
logP
5.5
logS
-5.4
pKa (Strongest Basic)
6.77
PSA
27.05 Å2
Refractivity
98.26 m3·mol-1
Polarizability
37.37 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Econazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). Econazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
Cơ Chế Tác Dụng : A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally. [PubChem] Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Dược Động Học :
▧ Absorption :
After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
▧ Metabolism :
Hepatic.
Độc Tính : Overdosage of econazole in humans has not been reported to date. In mice, rats guinea pigs and dogs, the oral LD 50 values were found to be 462, 668, 272, and > 160 mg/kg, respectively.
Chỉ Định : For topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.
Liều Lượng & Cách Dùng : Suppository - Intravaginal
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Sản phẩm biệt dược : Ecostatin
  • Công ty :
    Sản phẩm biệt dược : ECOZA
  • Công ty : Janssen
    Sản phẩm biệt dược : Gyno-Pevaryl
  • Công ty : Italfarmaco
    Sản phẩm biệt dược : Ifenec
  • Sản phẩm biệt dược : Palavale
  • Công ty : Janssen
    Sản phẩm biệt dược : Pevaryl
  • Công ty : Healthcare
    Sản phẩm biệt dược : Spectazole
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01127
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3198
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508881
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08068
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D03936
ChemSpider
http://www.chemspider.com/Chemical-Structure.3086.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0168-0312-15
PharmGKB
http://www.pharmgkb.org/drug/PA164746010
Wikipedia
http://en.wikipedia.org/wiki/Econazole
RxList
http://www.rxlist.com/cgi/generic3/econazole.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/spe1410.shtml
Drugs.com
http://www.drugs.com/cdi/econazole-cream.html
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