Tìm theo
Echothiophate
Các tên gọi khác (4 ) :
  • 2-(Diethoxyphosphorylsulfanyl)ethyl-N,N,N-trimethylazanium iodide
  • Echothiophate
  • Ecothiopatum
  • Phospholine
cholinesterase inhibitors, parasympathomimetics, miotics
Thuốc Gốc
Small Molecule
CAS: 6736-03-4
ĐG : Wyeth Pharmaceuticals , http://www.wyeth.com
CTHH: C9H23NO3PS
PTK: 256.323
A potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma. Occasionally used for accomodative esotropia.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H23NO3PS
Phân tử khối
256.323
Monoisotopic mass
256.113625809
InChI
InChI=1S/C9H23NO3PS/c1-6-12-14(11,13-7-2)15-9-8-10(3,4)5/h6-9H2,1-5H3/q+1
InChI Key
InChIKey=BJOLKYGKSZKIGU-UHFFFAOYSA-N
IUPAC Name
diethyl {[2-(trimethylazaniumyl)ethyl]sulfanyl}phosphonate
Traditional IUPAC Name
diethyl [2-(trimethylaminio)ethyl]sulfanylphosphonate
SMILES
CCOP(=O)(OCC)SCC[N+](C)(C)C
Độ tan chảy
124-124.5
Độ hòa tan
Soluble
logP
-2.25
logS
-3
pKa (Strongest Basic)
-8.2
PSA
35.53 Å2
Refractivity
78.14 m3·mol-1
Polarizability
27.65 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Echothiophate Iodide is a potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma. Echothiophate iodide will depress both plasma and erythrocyte cholinesterase levels in most patients after a few weeks of eyedrop therapy.
Cơ Chế Tác Dụng : A potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma. Occasionally used for accomodative esotropia. Echothiophate Iodide is a long-acting cholinesterase inhibitor for topical use which enhances the effect of endogenously liberated acetylcholine in iris, ciliary muscle, and other parasympathetically innervated structures of the eye. Echothiophate iodide binds irreversibly to cholinesterase, and is long acting due to the slow rate of hydrolysis by cholinesterase. It causes miosis, increase in facility of outflow of aqueous humor, fall in intraocular pressure, and potentiation of accommodation.
Dược Động Học :
▧ Absorption :
This ophthalmic medication may be systemically absorbed.
Độc Tính : Side effects include blurred vision or change in near or distant vision and eye pain. LD50: 174 mcg/kg in rats. (MSDS)
Chỉ Định : For use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated.
Tương Tác Thuốc :
  • Succinylcholine Echothiophate iodide may increase the effect of succinylcholine.
Liều Lượng & Cách Dùng : Solution / drops - Ophthalmic
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Alcon
    Sản phẩm biệt dược : Echodide
  • Công ty : Wyeth-Ayerst
    Sản phẩm biệt dược : Phospholine Iodide
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01057
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10547
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505944
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02193
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0046-1062-05
PharmGKB
http://www.pharmgkb.org/drug/PA164743139
Wikipedia
http://en.wikipedia.org/wiki/Echothiophate
RxList
http://www.rxlist.com/cgi/generic2/phospholine.htm
Drugs.com
http://www.drugs.com/cdi/echothiophate-eye-drops.html
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