Tìm theo
Dydrogesterone
Các tên gọi khác (17 ) :
  • (9β,10α)-pregna-4,6-diene-3,20-dione
  • 10alpha-Isopregnenone
  • 6-Dehydro-retro-progesterone
  • 9β,10α-pregna-4,6-diene-3,20-dione
  • delta(6)-Retroprogesterone
  • delta(Sup 6)-retroprogesterone
  • Didrogesterona
  • Didrogesterone
  • Dydrogesterona
  • Dydrogestérone
  • Dydrogesterone
  • Dydrogesteronum
  • Gestatron
  • Hydrogesterone
  • Hydrogestrone
  • Isopregnenone
  • Retro-6-dehydroprogesterone
Hormon, Nội tiết tố
Thuốc Gốc
Small Molecule
CAS: 152-62-5
ATC: G03DB01
CTHH: C21H28O2
PTK: 312.4458
A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H28O2
Phân tử khối
312.4458
Monoisotopic mass
312.20893014
InChI
InChI=1S/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4-5,12,16-19H,6-11H2,1-3H3/t16-,17+,18-,19+,20+,21+/m0/s1
InChI Key
InChIKey=JGMOKGBVKVMRFX-HQZYFCCVSA-N
IUPAC Name
(1R,2S,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-6,8-dien-5-one
Traditional IUPAC Name
dydrogesterone
SMILES
[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@]1([H])[C@@]2([H])C=CC2=CC(=O)CC[C@@]12C
Độ tan chảy
168-169
Độ hòa tan
4.86e-03 g/l
logP
3.4
logS
-4.8
pKa (strongest acidic)
19.29
pKa (Strongest Basic)
-4.8
PSA
34.14 Å2
Refractivity
93.82 m3·mol-1
Polarizability
36.39 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, dydrogesterone is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol. Dydrogesterone helps to regulate the healthy growth and normal shedding of the uterus lining. Therefore, it may be useful in the treatment of menstrual disorders such as absent, irregular or painful menstrual periods, infertility, premenstrual syndrome and endometriosis.
Cơ Chế Tác Dụng : A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation. [PubChem] Dydrogesterone is a progestogen that works by regulating the healthy growth and normal shedding of the womb lining by acting on progesterone receptors in the uterus.
Dược Động Học :
▧ Absorption :
Rapidly absorbed in the gastrointestinal tract with a bioavailability of 28%.
▧ Metabolism :
Metabolism is complete to a 20-dihydrodydrogesterone (DHD) metabolite.
▧ Half Life :
Dydrogesterone: 5-7 hours, 20-dihydrodydrogesterone (DHD) metabolite: 14-17 hours
Độc Tính : No serious or unexpected toxicity has been observed with dydrogesterone. In acute toxicity studies, the LD50 doses in rats exceeded 4,640mg/kg for the oral route.
Chỉ Định : Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Abbott
    Sản phẩm biệt dược : Dabroston
  • Công ty : Abbott
    Sản phẩm biệt dược : Dufaston
  • Công ty : Abbott
    Sản phẩm biệt dược : Duphaston
  • Công ty : Solvay
    Sản phẩm biệt dược : Terolut
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00378
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=9051
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506195
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01217
ChemSpider
http://www.chemspider.com/Chemical-Structure.8699.html
PharmGKB
http://www.pharmgkb.org/drug/PA164745443
Wikipedia
http://en.wikipedia.org/wiki/Dydrogesterone
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