Tìm theo
Dyclonine
Các tên gọi khác (11 ) :
  • 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone
  • 2-(1-Piperidyl)ethyl P-butoxyphenyl ketone
  • 3-Piperidino-4'-butoxypropiophenone
  • 4-Butoxy-beta-piperidinopropiophenone
  • 4-N-Butoxy-beta-(1-piperidyl)propiophenone
  • 4'-Butoxy-3-piperidinopropiophenone
  • Diclonina
  • Dyclocaine
  • Dyclonin
  • Dyclonine
  • Dycloninum
Thuốc gây mê
Thuốc Gốc
Small Molecule
CAS: 586-60-7
ATC: N01BX02, R02AD04
ĐG : Gallipot , http://www.gallipot.com
CTHH: C18H27NO2
PTK: 289.4125
Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H27NO2
Phân tử khối
289.4125
Monoisotopic mass
289.204179113
InChI
InChI=1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3
InChI Key
InChIKey=BZEWSEKUUPWQDQ-UHFFFAOYSA-N
IUPAC Name
1-(4-butoxyphenyl)-3-(piperidin-1-yl)propan-1-one
Traditional IUPAC Name
dyclonine
SMILES
CCCCOC1=CC=C(C=C1)C(=O)CCN1CCCCC1
Độ tan chảy
174-175
Độ hòa tan
Soluble (HCl salt)
logP
3.7
logS
-3.8
pKa (strongest acidic)
15.88
pKa (Strongest Basic)
8.36
PSA
29.54 Å2
Refractivity
87.07 m3·mol-1
Polarizability
35.14 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Dyclonine is an oral anasthetic. If substantial quantities of local anesthetics are absorbed through the mucosa, actions on the central nervous system (CNS) may cause CNS stimulation and/or CNS depression. Actions on the cardiovascular system may cause depression of cardiac conduction and excitability and, with some of these agents, peripheral vasodilation.
Cơ Chế Tác Dụng : Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray. Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
Dược Động Học :
▧ Absorption :
Readily absorbed through mucous membranes into the systemic circulation. The rate of absorption is influenced by the vascularity or rate of blood flow at the site of application, the total dosage (concentration and volume) administered, and the duration of exposure. Absorption from mucous membranes of the throat or respiratory tract may be especially rapid.
▧ Half Life :
Approximately 30 to 60 minutes.
Độc Tính : Symptoms of overdose include cardiovascular system depression, CNS toxicity, and methemoglobinemia.
Chỉ Định : Used to provide topical anesthesia of accessible mucous membranes prior to examination, endoscopy or instrumentation, or other procedures involving the esophagus, larynx, mouth, pharynx or throat, respiratory tract or trachea, urinary tract, or vagina. Also used to suppress the gag reflex and/or other laryngeal and esophageal reflexes to facilitate dental examination or procedures (including oral surgery), endoscopy, or intubation. Also used for relief of canker sores, cold sores or fever blister.
Liều Lượng & Cách Dùng : Lozenge - Oral
Spray - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Dyclonine hcl powder
    Giá bán buôn : USD >4.9
    Đơn vị tính : g
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00645
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3180
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506697
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07881
ChemSpider
http://www.chemspider.com/Chemical-Structure.3068.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748037
Wikipedia
http://en.wikipedia.org/wiki/Dyclonine
Drugs.com
http://www.drugs.com/cdi/dyclonine-lozenges.html
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