Tìm theo
Drostanolone
Các tên gọi khác (10 ) :
  • 17beta-Hydroxy-2alpha-methyl-5alpha-androstan-3-one
  • 2alpha-Methyldihydrotestosterone
  • Dihydro-2alpha-methyltestosterone
  • Dromostanolone
  • Drostanolona
  • Drostanolone
  • Drostanolonum
  • Medrosteron
  • Medrotestron
  • Metholone
Thuốc Gốc
Small Molecule
CAS: 58-19-5
CTHH: C20H32O2
PTK: 304.4669
Drostanolone (also known as dromostanolone) is a potent synthetic androgenic anabolic steroid similar to testosterone. Drostanolone is indicated in postmenopausal women with recurrent breast cancer, in a combined hormone therapy.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H32O2
Phân tử khối
304.4669
Monoisotopic mass
304.240230268
InChI
InChI=1S/C20H32O2/c1-12-11-20(3)13(10-17(12)21)4-5-14-15-6-7-18(22)19(15,2)9-8-16(14)20/h12-16,18,22H,4-11H2,1-3H3/t12-,13+,14+,15+,16+,18+,19+,20+/m1/s1
InChI Key
InChIKey=IKXILDNPCZPPRV-RFMGOVQKSA-N
IUPAC Name
(1S,2S,4R,7S,10R,11S,14S,15S)-14-hydroxy-2,4,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one
Traditional IUPAC Name
drostanolone
SMILES
[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)[C@H](C)C[C@]12C
Độ tan chảy
151 °C
Độ hòa tan
6.05e-03 g/l
logP
3.99
logS
-4.7
pKa (strongest acidic)
19.38
pKa (Strongest Basic)
-0.88
PSA
37.3 Å2
Refractivity
88.18 m3·mol-1
Polarizability
36.79 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Dromostanolone is a synthetic androgen, or male hormone, similar to testosterone. Dromostanolone works by attaching itself to androgen receptors; this causes it to interact with the parts of the cell involved in the making of proteins. It may cause an increase in the synthesis of some proteins or a decrease in the synthesis of others. These proteins have a variety of effects, including blocking the growth of some types of breast cancer cells, stimulating cells that cause male sexual characteristics, and stimulating the production of red blood cells.
Cơ Chế Tác Dụng : Drostanolone (also known as dromostanolone) is a potent synthetic androgenic anabolic steroid similar to testosterone. Drostanolone is indicated in postmenopausal women with recurrent breast cancer, in a combined hormone therapy. Dromostanolone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Dược Động Học :
▧ Absorption :
Well absorbed following parenteral administration.
Độc Tính : Side effects include virilization (masculine traits in women), acne, fluid retention, and hypercalcemia.
Chỉ Định : For use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Lilly
    Sản phẩm biệt dược : Drolban
  • Công ty : Syntex
    Sản phẩm biệt dược : Masteril
  • Công ty : Recordati
    Sản phẩm biệt dược : Masteron
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00858
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C14605
PharmGKB
http://www.pharmgkb.org/drug/PA164760855
Wikipedia
http://en.wikipedia.org/wiki/Drostanolone
... loading
... loading