Tìm theo
Dronabinol
Các tên gọi khác (13 ) :
  • (-)-delta9-trans-Tetrahydrocannabinol
  • 1-trans-delta-9-Tetrahydrocannabinol
  • 3-Pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo(b,D)pyran-1-ol
  • 6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
  • delta-9-tetrahydrocannabinol
  • delta-9-THC
  • delta(1)-Tetrahydrocannabinol
  • delta(9)-THC
  • delta9-Tetrahydrocannabinol
  • Dronabinol
  • Dronabinolum
  • Tetrahydrocannabinol
  • Δ9-tetrahydrocannabinol
analgesics non narcotic, cannabinoid receptor agonists, hallucinogens, psychotropic drugs
Thuốc Gốc
Small Molecule
CAS: 1972-08-3
ATC: A04AD10
ĐG : Banner Pharmacaps Inc. , http://www.banpharm.com
CTHH: C21H30O2
PTK: 314.4617
A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound. Dronabinol is a synthetic form of delta-9-THC. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H30O2
Phân tử khối
314.4617
Monoisotopic mass
314.224580204
InChI
InChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/m1/s1
InChI Key
InChIKey=CYQFCXCEBYINGO-IAGOWNOFSA-N
IUPAC Name
(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6H,6aH,7H,8H,10aH-benzo[c]isochromen-1-ol
Traditional IUPAC Name
THC
SMILES
[H][C@@]12C=C(C)CC[C@@]1([H])C(C)(C)OC1=C2C(O)=CC(CCCCC)=C1
Độ tan chảy
200 °C at 2.00E-02 mm Hg
Độ hòa tan
2800 mg/L (at 23 °C)
logP
5.648
logS
-5.1
pKa (strongest acidic)
9.34
pKa (Strongest Basic)
-4.9
PSA
29.46 Å2
Refractivity
96.73 m3·mol-1
Polarizability
38.96 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
3
Bioavailability
1
pKa
10.6
Dược Lực Học : Marinol may has complex effects on the central nervous system (CNS), including cannabinoid receptors. Dronabinol may inhibit endorphins in the emetic center, suppress prostaglandin synthesis, and/or inhibit medullary activity through an unspecified cortical action.
Cơ Chế Tác Dụng : A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound. Dronabinol is a synthetic form of delta-9-THC. [PubChem] The mechanism of action of marinol is not completely understood. It is thought that cannabinoid receptors in neural tissues may mediate the effects of dronabinol and other cannabinoids. Animal studies with other cannabinoids suggest that marinol's antiemetic effects may be due to inhibition of the vomiting control mechanism in the medulla oblongata.
Dược Động Học :
▧ Absorption :
90 - 95%
▧ Volume of Distribution :
* 10 L/kg
▧ Protein binding :
97%
▧ Metabolism :
Hepatic
▧ Route of Elimination :
Dronabinol and its biotransformation products are excreted in both feces and urine.
▧ Half Life :
Alpha phase: approximately 4 hours; Beta phase: 25-36 hours
▧ Clearance :
* 0.2 L/kg-hr
Chỉ Định : For the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments
Tương Tác Thuốc :
  • Trimethobenzamide Anticholinergics, such as Trimethobenzamide, may increase the tachycardic effect of cannabinoids such as Marinol. Close monitoring of cardiovascular effects is recommended.
  • Trospium Anticholinergics, such as Trospium, may increase the tachycardic effect of cannabinoids such as Marinol. Close monitoring of cardiovascular effects is recommended.
Liều Lượng & Cách Dùng : Capsule - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Marinol
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00470
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06972
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00306
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50007391
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0051-0021-21
PharmGKB
http://www.pharmgkb.org/drug/PA449421
Wikipedia
http://en.wikipedia.org/wiki/Marinol
RxList
http://www.rxlist.com/cgi/generic2/drona.htm
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