Tìm theo
Doxapram
Các tên gọi khác (4 ) :
  • (+-)-Doxapram
  • 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone
  • Doxapram
  • Doxapramum
Thuốc Gốc
Small Molecule
CAS: 309-29-5
ATC: R07AB01
ĐG : Baxter International Inc. , http://www.baxter.com
CTHH: C24H30N2O2
PTK: 378.5072
A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C24H30N2O2
Phân tử khối
378.5072
Monoisotopic mass
378.230728214
InChI
InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3
InChI Key
InChIKey=XFDJYSQDBULQSI-UHFFFAOYSA-N
IUPAC Name
1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one
Traditional IUPAC Name
(+-)-doxapram
SMILES
CCN1CC(CCN2CCOCC2)C(C1=O)(C1=CC=CC=C1)C1=CC=CC=C1
Độ tan chảy
217-219
Độ hòa tan
Sparingly soluble
logP
3.6
logS
-4
pKa (Strongest Basic)
7.23
PSA
32.78 Å2
Refractivity
112.85 m3·mol-1
Polarizability
43.02 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Doxapram is an analeptic agent (a stimulant of the central nervous system). The respiratory stimulant action is manifested by an increase in tidal volume associated with a slight increase in respiratory rate. A pressor response may result following doxapram administration. Provided there is no impairment of cardiac function, the pressor effect is more marked in hypovolemic than in normovolemic states. The pressor response is due to the improved cardiac output rather than peripheral vasoconstriction. Following doxapram administration, an increased release of catecholamines has been noted.
Cơ Chế Tác Dụng : A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225) Doxapram produces respiratory stimulation mediated through the peripheral carotid chemoreceptors. It is thought to stimulate the carotid body by inhibiting certain potassium channels.
Độc Tính : Intravenous LD50 values in the mouse and rat were approximately 75 mg/kg and in the cat and dog were 40 to 80 mg/kg. Symptoms of overdosage are extensions of the pharmacologic effects of the drug. Excessive pressor effect, tachycardia, skeletal muscle hyperactivity, and enhanced deep tendon reflexes may be early signs of overdosage.
Chỉ Định : For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease.
Liều Lượng & Cách Dùng : Injection, solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Khandelwal
    Sản phẩm biệt dược : Caropram
  • Sản phẩm biệt dược : Dai Er Song
  • Công ty : Baxter
    Sản phẩm biệt dược : Dopram
  • Công ty : Nhwa
    Sản phẩm biệt dược : Jia Su Lun
  • Công ty :
    Sản phẩm biệt dược : Stimulex
  • Sản phẩm biệt dược : Ze Lun
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00561
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3156
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506829
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01872
ChemSpider
http://www.chemspider.com/Chemical-Structure.3044.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/55390-035-01
PharmGKB
http://www.pharmgkb.org/drug/PA164784026
Wikipedia
http://en.wikipedia.org/wiki/Doxapram
RxList
http://www.rxlist.com/cgi/generic2/doxapram.htm
Drugs.com
http://www.drugs.com/cdi/doxapram.html
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