Tìm theo
Docosanol
Các tên gọi khác (9 ) :
  • 1-Docosanol
  • Abreva
  • Behenic alcohol
  • Behenyl alcohol
  • Docosan-1-ol
  • Docosanol
  • Docosyl alcohol
  • N-Docosanol
  • Tadenan
antiviral agents, dermatologic agents
Thuốc Gốc
Small Molecule
CAS: 30303-65-2
ATC: D06BB11
ĐG : GlaxoSmithKline Inc. , http://www.gsk.com
CTHH: C22H46O
PTK: 326.6
Docosanol is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters). A saturated 22-carbon aliphatic alcohol, docosanol exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Docosanol inhibits fusion between the plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H46O
Phân tử khối
326.6
Monoisotopic mass
326.354866094
InChI
InChI=1S/C22H46O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23/h23H,2-22H2,1H3
InChI Key
InChIKey=NOPFSRXAKWQILS-UHFFFAOYSA-N
IUPAC Name
docosan-1-ol
Traditional IUPAC Name
docosanol
SMILES
CCCCCCCCCCCCCCCCCCCCCCO
Độ tan chảy
65-72 °C
Độ hòa tan
1.96e-05 g/l
logP
9
logS
-7.2
pKa (strongest acidic)
16.84
pKa (Strongest Basic)
-2
PSA
20.23 Å2
Refractivity
104.95 m3·mol-1
Polarizability
47.27 Å3
Rotatable Bond Count
20
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
0
Bioavailability
0
Dược Lực Học : Docosanol is a saturated 22-carbon aliphatic alcohol which exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Docosanol speeds the healing of cold sores and fever blisters on the face or lips. It also relieves the accompanying symptoms, including tingling, pain, burning, and itching. Docosanol cannot, however, prevent cold sores or fever blisters from appearing.
Cơ Chế Tác Dụng : Docosanol is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters). A saturated 22-carbon aliphatic alcohol, docosanol exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Docosanol inhibits fusion between the plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication. Docosanol works by inhibiting fusion between the human cell plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication. Unlike other cold-sore antivirals, docosanol does not act directly on the virus, and as such it is unlikely it will produce drug resistant mutants of HSV.
Dược Động Học :
▧ Absorption :
Topical absorption has been shown to be minimal under conditions reflecting normal clinical use.
Độc Tính : Symptoms of overdose include headache, abdominal pain, increased serum lipase, nausea, dyspepsia, dizziness, and hyperbilirubinemia.
Chỉ Định : For the topical treatment of recurrent oral-facial herpes simplex episodes (cold sores or fever blisters).
Liều Lượng & Cách Dùng : Cream - Topical
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Abreva 10% cream
    Giá bán buôn : USD >7.57
    Đơn vị tính : g
Nhà Sản Xuất
  • Công ty : GlaxoSmithKline
    Sản phẩm biệt dược : Abreva
  • Công ty : DDD
    Sản phẩm biệt dược : Blistex
  • Công ty : Healthcare
    Sản phẩm biệt dược : Erazaban
  • Công ty : Aco Hud
    Sản phẩm biệt dược : Healip
  • Công ty : Incepta
    Sản phẩm biệt dược : Lafrost
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00632
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=12620
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508049
ChemSpider
http://www.chemspider.com/Chemical-Structure.12100.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0135-0200-01
PharmGKB
http://www.pharmgkb.org/drug/PA164749211
Wikipedia
http://en.wikipedia.org/wiki/Docosanol
Drugs.com
http://www.drugs.com/cdi/docosanol.html
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