Tìm theo
Diphenylpyraline
Các tên gọi khác (7 ) :
  • 1-Methyl-4-hydroxypiperidine benzhydryl ether
  • 1-Methyl-4-piperidyl benzhydryl ether
  • 4-(Benzhydryloxy)-1-methylpiperidine
  • 4-(Benzhydryloxy)-N-methylpiperidine
  • Difenilpiralina
  • Diphenylpyralamine
  • Diphenylpyralinum
histamine antagonists
Thuốc Gốc
Small Molecule
CAS: 147-20-6
ATC: R06AA07, V01AA02, V01AA20
CTHH: C19H23NO
PTK: 281.392
Diphenylpyraline is an antihistamine. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells. Antihistamines prevent, but do not reverse, responses mediated by histamine alone. Antihistamines antagonize, in varying degrees, most of the pharmacological effects of histamine, including urticaria and pruritus.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H23NO
Phân tử khối
281.392
Monoisotopic mass
281.177964363
InChI
InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3
InChI Key
InChIKey=OWQUZNMMYNAXSL-UHFFFAOYSA-N
IUPAC Name
4-(diphenylmethoxy)-1-methylpiperidine
Traditional IUPAC Name
diphenylpyraline
SMILES
CN1CCC(CC1)OC(C1=CC=CC=C1)C1=CC=CC=C1
Độ tan chảy
206
Độ hòa tan
1.88e-02 g/l
logP
3.7
logS
-4.2
pKa (Strongest Basic)
8.87
PSA
12.47 Å2
Refractivity
87.36 m3·mol-1
Polarizability
32.97 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Diphenylpyraline is an antihistamine that prevents, but does not reverse, responses mediated by histamine alone. Diphenylpyraline antagonizes most of the pharmacological effects of histamine, including urticaria and pruritus. Also, diphenylpyraline may exhibit anticholinergic actions (as do most of the antihistamines) and may thus provide a drying effect on the nasal mucosa.
Cơ Chế Tác Dụng : Diphenylpyraline is an antihistamine. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells. Antihistamines prevent, but do not reverse, responses mediated by histamine alone. Antihistamines antagonize, in varying degrees, most of the pharmacological effects of histamine, including urticaria and pruritus. Antihistamines such as diphenylpyraline used in the treatment of allergy act by competing with histamine for H1-receptor sites on effector cells. This reduces the effects of histamine, leading to a temporary reduction of allergy symptoms.
Dược Động Học :
▧ Absorption :
Well absorbed after oral administration.
▧ Protein binding :
> 99% in human serum albumin
▧ Metabolism :
Hepatic
Chỉ Định : For use in the treatment of allergic rhinitis, hay fever, and allergic skin disorders.
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Liquid - Intradermal
Liquid - Subcutaneous
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Allergen
  • Công ty :
    Sản phẩm biệt dược : Arbid
  • Công ty :
    Sản phẩm biệt dược : Belfene
  • Công ty : Riker
    Sản phẩm biệt dược : Diafen
  • Công ty : Nopco
    Sản phẩm biệt dược : Hispril
  • Công ty :
    Sản phẩm biệt dược : Histyn
  • Công ty :
    Sản phẩm biệt dược : Lergobine
  • Công ty : Lyssia
    Sản phẩm biệt dược : Lyssipoll
  • Công ty :
    Sản phẩm biệt dược : Mepiben
  • Công ty :
    Sản phẩm biệt dược : Neargal
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01146
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3103
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504936
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01172
ChemSpider
http://www.chemspider.com/Chemical-Structure.2992.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241333
PharmGKB
http://www.pharmgkb.org/drug/PA164746377
Wikipedia
http://en.wikipedia.org/wiki/Diphenylpyraline
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