Tìm theo
Diphenidol
Các tên gọi khác (6 ) :
  • alpha,alpha-Diphenyl-1-piperidinebutanol
  • Difenidol
  • Difenidolo
  • Difenidolum
  • Diphenidol
  • Diphenyl(3-(1-piperidyl)propyl)carbinol
antiemetics
Thuốc Gốc
Small Molecule
CAS: 972-02-1
ĐG : Professional Co.
CTHH: C21H27NO
PTK: 309.4452
Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo. Diphenidol overdose may result in serious toxicity in children.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H27NO
Phân tử khối
309.4452
Monoisotopic mass
309.209264491
InChI
InChI=1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2
InChI Key
InChIKey=OGAKLTJNUQRZJU-UHFFFAOYSA-N
IUPAC Name
1,1-diphenyl-4-(piperidin-1-yl)butan-1-ol
Traditional IUPAC Name
diphenidol
SMILES
OC(CCCN1CCCCC1)(C1=CC=CC=C1)C1=CC=CC=C1
Độ tan chảy
212-214
Độ hòa tan
5.87e-03 g/l
logP
4.3
logS
-4.7
pKa (strongest acidic)
13.4
pKa (Strongest Basic)
9.23
PSA
23.47 Å2
Refractivity
96.92 m3·mol-1
Polarizability
36.66 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Diphenidol is used for control of nausea and vomiting. It has an antivertigo effect on the vestibular apparatus, inhibiting the chemoreceptor trigger zone to control nausea and vomiting, thus preventing motion sickness.
Cơ Chế Tác Dụng : Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo. Diphenidol overdose may result in serious toxicity in children. The mechanism by which diphenidol exerts its antiemetic and antivertigo effects is not precisely known. It is thought to diminish vestibular stimulation and depress labyrinthine function and as an antimuscarinic agent. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect. Diphenidol has no significant sedative, tranquilizing, or antihistaminic action. It has a weak peripheral anticholinergic effect.
Dược Động Học :
▧ Absorption :
Well absorbed from gastrointestinal tract following oral administration.
▧ Half Life :
4 hours
Độc Tính : Symptoms of overdose include drowsiness (severe); shortness of breath or troubled breathing; unusual tiredness or weakness (severe).
Chỉ Định : For use in the prevention and symptomatic treatment of peripheral (labyrinthine) vertigo and associated nausea and vomiting that occur in such conditions as Meniere's disease and surgery of the middle and inner ear. Also for the control of nausea and vomiting associated with postoperative states, malignant neoplasms, labyrinthine disturbances, antineoplastic agent therapy, radiation sickness, and infectious diseases.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Tatsumi Kagaku
    Sản phẩm biệt dược : Satanolon
  • Công ty :
    Sản phẩm biệt dược : Verterge
  • Công ty : Sanfer
    Sản phẩm biệt dược : Vontrol
  • Công ty :
    Sản phẩm biệt dược : Yesdol
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01231
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3055
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506486
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06961
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D03858
ChemSpider
http://www.chemspider.com/Chemical-Structure.2947.html
PharmGKB
http://www.pharmgkb.org/drug/PA164746037
Drugs.com
http://www.drugs.com/cons/diphenidol.html
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