Tìm theo
Diphemanil Methylsulfate
Các tên gọi khác (10 ) :
  • 4-(Diphenylmethylene)-1,1-dimethylpiperidinium methyl sulfate
  • Diphemanil methosulfate
  • Diphemanil methylsulfat
  • Diphemanil metilsulfate
  • Diphemanili metilsulfas
  • Métilsulfate de Diphémanil
  • Metilsulfato de difemanilo
  • N,N-Dimethyl-4-piperidylidene-1,1-diphenylmethane methylsulfate
  • P-(alpha-Phenylbenzylidene)-1,1-dimethylpiperidinium methyl sulfate
  • Vagophemanil
Thuốc Gốc
Small Molecule
CAS: 62-97-5
ATC: A03AB15
CTHH: C21H27NO4S
PTK: 389.508
Diphemanil Methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H27NO4S
Phân tử khối
389.508
Monoisotopic mass
389.166079047
InChI
InChI=1S/C20H24N.CH4O4S/c1-21(2)15-13-19(14-16-21)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;1-5-6(2,3)4/h3-12H,13-16H2,1-2H3;1H3,(H,2,3,4)/q+1;/p-1
InChI Key
InChIKey=BREMLQBSKCSNNH-UHFFFAOYSA-M
IUPAC Name
4-(diphenylmethylidene)-1,1-dimethylpiperidin-1-ium methyl sulfate
Traditional IUPAC Name
4-(diphenylmethylidene)-1,1-dimethylpiperidin-1-ium methyl sulfate
SMILES
COS([O-])(=O)=O.C[N+]1(C)CCC(CC1)=C(C1=CC=CC=C1)C1=CC=CC=C1
Độ tan chảy
196-197
Độ hòa tan
2.04e-04 g/l
logP
2.57
logS
-6.3
Refractivity
111.69 m3·mol-1
Polarizability
33.56 Å3
Polar Surface Area (PSA)
0
Rotatable Bond Count
3
H Bond Acceptor Count
0
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Diphemanil Methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.
Cơ Chế Tác Dụng : Diphemanil Methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat. Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. M3 receptors are located in the smooth muscles of the blood vessels, as well as in the lungs. This means they cause vasodilation and bronchoconstriction. They are also in the smooth muscles of the gastrointestinal tract (GIT), which help in increasing intestinal motility and dilating sphincters. The M3 receptors are also located in many glands which help to stimulate secretion in salivary glands and other glands of the body.
Dược Động Học :
▧ Absorption :
Poorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%.
Chỉ Định : Used in the treatment of peptic ulcer, gastric hyperacidity, and hypermotility in gastritis and pylorospasm, and in the treatment of hyperhidrosis (excessive perspiration).
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Pharmacia
    Sản phẩm biệt dược : Demotil
  • Công ty : Schering-Plough
    Sản phẩm biệt dược : Prantal
  • Công ty : Essex
    Sản phẩm biệt dược : Prentol
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00729
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6126
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506069
ChemSpider
http://www.chemspider.com/Chemical-Structure.5896.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748388
... loading
... loading