Tìm theo
Diosmin
Thuốc Gốc
Small Molecule
CAS: 520-27-4
CTHH: C28H32O15
PTK: 608.5447
Diosmin is a semisynthetic drug indicated for the treatment of venous disease. Diosmin is a flavone that can be found in the plant Teucrium gnaphalodes. Diosmin is available as a prescription medicine in several European countries, and is available as a nutritional supplement in the United States and the rest of Europe. It should be noted that clinical studies have been inconclusive and no articles have been published pertaining to its use in the treatment of vascular disease. When used in rats, diosmin has been effective at mitigating hyperglycaemia, and may also have antineurodegenerative properties.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C28H32O15
Phân tử khối
608.5447
Monoisotopic mass
608.174120354
InChI
InChI=1/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/s2
InChI Key
InChIKey=GZSOSUNBTXMUFQ-DSPCJXANNA-N
IUPAC Name
5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-4H-chromen-4-one
Traditional IUPAC Name
diosmin
SMILES
[H][C@@]1(C)O[C@@]([H])(OC[C@@]2([H])O[C@@]([H])(OC3=CC(O)=C4C(=O)C=C(OC4=C3)C3=CC(O)=C(OC)C=C3)[C@]([H])(O)[C@@]([H])(O)[C@]2([H])O)[C@]([H])(O)[C@]([H])(O)[C@@]1([H])O
Độ hòa tan
1.54e+00 g/l
logP
-0.44
logS
-2.6
pKa (strongest acidic)
8.48
pKa (Strongest Basic)
-3.6
PSA
234.29 Å2
Refractivity
142.39 m3·mol-1
Polarizability
59.32 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
15
H Bond Donor Count
8
Physiological Charge
0
Number of Rings
5
Bioavailability
0
MDDR-Like Rule
true
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Servier
    Sản phẩm biệt dược : Dalfon
  • Công ty :
    Sản phẩm biệt dược : Detralex
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08995
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07858
Wikipedia
http://en.wikipedia.org/wiki/Diosmin
Drugs.com
http://www.drugs.com/international/diosmin.html
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