Tìm theo
Dinoprost Tromethamine
Các tên gọi khác (7 ) :
  • Dinoprost trometamol
  • PGF2-alpha THAM
  • PGF2alpha THAM
  • Prostaglandin F2-alpha THAM
  • Prostaglandin F2a tromethamine
  • Prostaglandin F2alpha tham
  • Prostin F2 Alpha
oxytocics, abortifacient agents nonsteroidal, angiography, stimulants uterine
Thuốc Gốc
Small Molecule
CAS: 38562-01-5
ATC: G02AD01
ĐG : Pfizer Inc. , http://www.pfizer.com
CTHH: C24H45NO8
PTK: 475.616
The tromethamine (THAM) salt of the naturally occurring prostaglandin F2 alpha, dinoprost tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder. Dinoprost tromethamine may also be known as dinoprost trometamol, PGF2 alpha THAM, or prostaglandin F2 alpha tromethamine.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C24H45NO8
Phân tử khối
475.616
Monoisotopic mass
475.314517421
InChI
InChI=1S/C20H34O5.C4H11NO3/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25;5-4(1-6,2-7)3-8/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25);6-8H,1-3,5H2/b7-4-,13-12+;/t15-,16+,17+,18-,19+;/m0./s1
InChI Key
InChIKey=IYGXEHDCSOYNKY-RZHHZEQLSA-N
IUPAC Name
(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]cyclopentyl]hept-5-enoic acid; 2-amino-2-(hydroxymethyl)propane-1,3-diol
Traditional IUPAC Name
THAM; dinoprost
SMILES
OCC(N)(CO)CO.CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
Độ tan chảy
100-101
Độ hòa tan
0.2 g/mL
logP
-0.12
pKa (strongest acidic)
4.36
pKa (Strongest Basic)
-1.6
PSA
97.99 Å2
Refractivity
100.47 m3·mol-1
Polarizability
41.56 Å3
Rotatable Bond Count
15
H Bond Acceptor Count
5
H Bond Donor Count
4
Physiological Charge
-1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : Dinoprost tromethamine is the tromethamine (THAM) salt of the naturally occurring prostaglandin F2alpha. Prostaglandin F2alpha has several pharmacologic effects on the female reproductive system, including stimulation of myometrial activity, relaxation of the cervix, inhibition of steroidogenesis by corpora lutea, and can potentially lyse corpora lutea.
Cơ Chế Tác Dụng : The tromethamine (THAM) salt of the naturally occurring prostaglandin F2 alpha, dinoprost tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder. Dinoprost tromethamine may also be known as dinoprost trometamol, PGF2 alpha THAM, or prostaglandin F2 alpha tromethamine. Dinoprost tromethamine appears to act directly on the myometrium, but this has not been completely established. Dinoprost stimulates myometrial contractions (via its interaction with the prostaglandin receptors) in the gravid uterus that are similar to the contractions that occur in the term uterus during labor. These contractions are usually sufficient to cause abortion. Uterine response to prostaglandins increases gradually throughout pregnancy. Dinoprost also facilitates cervical dilatation and softening.
Dược Động Học :
▧ Absorption :
Slowly absorbed from the amniotic fluid into systemic circulation.
▧ Metabolism :
Enzymatic dehydrogenation primarily in the maternal lungs and also in the liver.
▧ Half Life :
The half-life of dinoprost in amniotic fluid is 3 to 6 hours. The plasma half-life of dinoprost after intravenous administration is reported to be less than 1 minute.
Độc Tính : Although overdose by intra-amniotic administration of dinoprost has not been reported, exaggeration of the nausea, vomiting, and diarrhea that occur with normal doses would be expected.
Chỉ Định : Used for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities incompatible with life. Also used at low-doses for medically indicated induction of labor at term. Also injected intra-arterially for use as a vasodilator to assist in angiography.
Liều Lượng & Cách Dùng : Solution - Intra-amniotic
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Pfizer
    Sản phẩm biệt dược : Dinolytic
  • Công ty : Chinoin
    Sản phẩm biệt dược : Enzaprost F
  • Công ty : Fuji Yakuhin
    Sản phẩm biệt dược : Prosmon
  • Công ty : Pfizer
    Sản phẩm biệt dược : Prostin F2 Alpha
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01160
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5282415
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46509164
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01352
ChemSpider
http://www.chemspider.com/Chemical-Structure.4445570.html
PharmGKB
http://www.pharmgkb.org/drug/PA164781385
Wikipedia
http://en.wikipedia.org/wiki/Prostaglandin_F2alpha
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