Tìm theo
Dimethyl sulfoxide
Các tên gọi khác (12 ) :
  • (CH3)2SO
  • Dimethyl sulfoxide
  • Dimethyl sulfur oxide
  • Dimethyl sulphoxide
  • Dimethyli sulfoxidum
  • Dimethylsulfoxid
  • Dimethylsulfoxyde
  • Dimetil sulfoxido
  • DMSO
  • Methylsulfinylmethane
  • S(O)Me2
  • Sulfinylbis(methane)
free radical scavengers, solvents, cryoprotective agents
Thuốc Gốc
Small Molecule
CAS: 67-68-5
ATC: G04BX13, M02AX03
ĐG : Ben Venue Laboratories Inc. , http://www.benvenue.com
CTHH: C2H6OS
PTK: 78.133
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C2H6OS
Phân tử khối
78.133
Monoisotopic mass
78.013935504
InChI
InChI=1S/C2H6OS/c1-4(2)3/h1-2H3
InChI Key
InChIKey=IAZDPXIOMUYVGZ-UHFFFAOYSA-N
IUPAC Name
methanesulfinylmethane
Traditional IUPAC Name
dimethyl sulfoxide
SMILES
CS(C)=O
Độ tan chảy
18.5 °C
Độ sôi
63
Độ hòa tan
1E+006 mg/L
logP
-1.35
logS
-0.08
pKa (Strongest Basic)
-6.2
PSA
17.07 Å2
Refractivity
20.73 m3·mol-1
Polarizability
7.91 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Dimethyl Sulfoxide may have anti-inflammatory, antioxidant and analgesic activities. Dimethyl Sulfoxide also readily penetrates cellular membranes. The membrane-penetrating ability of dimethyl sulfoxide may enhance diffusion of other substances through the skin. For this reason, mixtures of idoxuridine and dimethyl sulfoxide have been used for topical treatment of herpes zoster in the United Kingdom.
Cơ Chế Tác Dụng : A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation. [PubChem] The mechanism of dimethyl sulfoxide's actions is not well understood. Dimethyl sulfoxide has demonstrated antioxidant activity in certain biological settings. For example, the cardiovascular protective effect of dimethyl sulfoxide in copper-deficient rats is thought to occur by an antioxidant mechanism. It is also thought that dimethyl sulfoxide's possible anti-inflammatory activity is due to antioxidant action.
Dược Động Học :
▧ Absorption :
Readily and rapidly absorbed following administration by all routes and distributed throughout the body.
▧ Metabolism :
Dimethyl sulfoxide is metabolized in man by oxidation to dimethyl sulfone or by reduction in dimethyl sulfide. Dimethyl sulfoxide and dimethyl sulfone are excreted in the urine and feces.
▧ Route of Elimination :
Dimethyl sulfoxide and dimethyl sulfone are excreted in the urine and feces.
Độc Tính : The oral LD50 of dimethyl sulfoxide in the dog is greater than 10 gm/kg. It is improbable that this dosage level could be obtained with intravesical instillation of dimethyl sulfoxide in the patient.
Chỉ Định : For the symptomatic relief of patients with interstitial cystitis.
Liều Lượng & Cách Dùng : Solution - Intravesical
Solution - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Alveda
    Sản phẩm biệt dược : Rimso-50
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01093
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=679
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505009
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C11143
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01043
ChemSpider
http://www.chemspider.com/Chemical-Structure.659.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/67457-177-50
PharmGKB
http://www.pharmgkb.org/drug/PA449342
Wikipedia
http://en.wikipedia.org/wiki/Dimethyl_sulfoxide
RxList
http://www.rxlist.com/cgi/generic/dmso.htm
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/dim_0098.shtml
Drugs.com
http://www.drugs.com/cdi/dimethyl-sulfoxide.html
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