Tìm theo
Dimetacrine
Các tên gọi khác (6 ) :
  • 3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine
  • Dimetacrine
  • Istonil
  • Istonyl
  • Linostil
  • Miroistonil
Thuốc Gốc
Small Molecule
CAS: 4757-55-5
CTHH: C20H26N2
PTK: 294.4338
Dimetacrine (Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) with imipramine-like effects used in Europe and formerly in Japan for the treatment of depression.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H26N2
Phân tử khối
294.4338
Monoisotopic mass
294.209598842
InChI
InChI=1S/C20H26N2/c1-20(2)16-10-5-7-12-18(16)22(15-9-14-21(3)4)19-13-8-6-11-17(19)20/h5-8,10-13H,9,14-15H2,1-4H3
InChI Key
InChIKey=RYQOGSFEJBUZBX-UHFFFAOYSA-N
IUPAC Name
[3-(9,9-dimethyl-9,10-dihydroacridin-10-yl)propyl]dimethylamine
Traditional IUPAC Name
dimetacrine
SMILES
CN(C)CCCN1C2=CC=CC=C2C(C)(C)C2=CC=CC=C12
Độ tan chảy
155-156
Độ hòa tan
3.43e-02 g/l
logP
4.42
logS
-3.9
pKa (Strongest Basic)
9.2
PSA
6.48 Å2
Refractivity
105.52 m3·mol-1
Polarizability
35.87 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Little is known about the pharmacology of dimetacrine.
Dược Động Học :

▧ Volume of Distribution :
The highest concentrations of dimetacrine were found at 1 hour after administration but at 3 hours in brain, heart, lung, liver, spleen, kidney, skeletal muscle and adipose tissue of testes. (Carried out in mice, PMID 5312397).
▧ Route of Elimination :
Approximately 70% of the doses were excreted in urine and feces within 2 days after treatment. (PMID 5312397)
▧ Half Life :
Approximately 10 hours. (PMID 5312397)
Độc Tính : Dimetacrine may induce severe cardiac toxicity in overdose. This property is unique among the tricyclic antidepressants.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08996
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C12959
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02565
Wikipedia
http://en.wikipedia.org/wiki/Dimetacrine
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