Tìm theo
Dihydrotachysterol
Các tên gọi khác (6 ) :
  • Anti-tetany substance 10
  • AT 10
  • Dihidrotaquisterol
  • Dihydrotachysterol
  • Dihydrotachysterolum
  • Vitamin D4
bone density conservation agents, vitamins, antithyroid agents, vitamin d, antihypocalcemic agents
Thuốc Gốc
Small Molecule
CAS: 67-96-9
ATC: A11CC02
ĐG : Murfreesboro Pharmaceutical Nursing Supply , http://www.unitdosesupply.com
CTHH: C28H46O
PTK: 398.6642
A vitamin D that can be regarded as a reduction product of vitamin D2. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C28H46O
Phân tử khối
398.6642
Monoisotopic mass
398.354866094
InChI
InChI=1S/C28H46O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-22,25-27,29H,7-8,11,14-18H2,1-6H3/b10-9+,23-12+,24-13+/t20-,21-,22+,25-,26+,27-,28+/m0/s1
InChI Key
InChIKey=ILYCWAKSDCYMBB-OPCMSESCSA-N
IUPAC Name
(1S,3E,4S)-3-{2-[(1R,3aS,4E,7aR)-1-[(2R,3E,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylcyclohexan-1-ol
Traditional IUPAC Name
dihydrotachysterol
SMILES
CC(C)[C@@H](C)\C=C\[C@@H](C)[C@@]1([H])CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1/C[C@@H](O)CC[C@@H]1C
Độ hòa tan
1.25e-04 g/l
logP
7.5
logS
-6.5
pKa (strongest acidic)
18.3
pKa (Strongest Basic)
-1.4
PSA
20.23 Å2
Refractivity
129.11 m3·mol-1
Polarizability
51.76 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Dược Lực Học : Dihydrotachysterol is hydroxylated in the liver to 25-hydroxydihydrotachysterol, which is the major circulating active form of the drug. It does not undergo further hydroxylation by the kidney and therefore is the analogue of 1, 25-dihydroxyvitamin D. Dihydrotachysterol is effective in the elevation of serum calcium by stimulating intestinal calcium absorption and mobilizing bone calcium in the absence of parathyroid hormone and of functioning renal tissue. Dihydrotachysterol also increases renal phosphate excretion.
Cơ Chế Tác Dụng : A vitamin D that can be regarded as a reduction product of vitamin D2. [PubChem] Once hydroxylated to 25-hydroxydihydrotachysterol, the modified drug binds to the vitamin D receptor. The bound form of the vitamin D receptor serves as a transcriptional regulator of bone matrix proteins, inducing the expression of osteocalcin and suppressing synthesis of type I collagen. Vitamin D (when bound to the vitamin D receptor)stimulates the expression of a number of proteins involved in transporting calcium from the lumen of the intestine, across the epithelial cells and into blood. This stimulates intestinal calcium absorption and increases renal phosphate excretion. These are functions that are normally carried out by the parathyroid hormone.
Dược Động Học :

▧ Protein binding :
>99%
Độc Tính : Toxicity associated with dihydrotachysterol is similar to that seen with large doses of vitamin D.
Chỉ Định : Used for the prevention and treatment of rickets or osteomalacia, and to manage hypocalcemia associated with hypoparathyroidism or pseudohypoparathyroidism. Also used for the treatment of vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).
Liều Lượng & Cách Dùng : Solution, concentrate - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Bayer
    Sản phẩm biệt dược : Atiten
  • Công ty : Solvay
    Sản phẩm biệt dược : Dihydral
  • Công ty : Dishman
    Sản phẩm biệt dược : Dygratyl
  • Công ty :
    Sản phẩm biệt dược : Hytakerol
  • Công ty : Chauvin
    Sản phẩm biệt dược : Tachystin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01070
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06957
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00299
PharmGKB
http://www.pharmgkb.org/drug/PA164744345
Wikipedia
http://en.wikipedia.org/wiki/Dihydrotachysterol
RxList
http://www.rxlist.com/cgi/generic/dhtinten.htm
Drugs.com
http://www.drugs.com/mtm/dihydrotachysterol.html
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