Tìm theo
Dihomo-γ-linolenic acid
Các tên gọi khác (21 ) :
  • (8Z,11Z,14Z)-Icosatrienoic acid
  • (Z,Z,Z)-8,11,14-Eicosatrienoic acid
  • (Z,Z,Z)-8,11,14-Icosatrienoate
  • (Z,Z,Z)-8,11,14-Icosatrienoic acid
  • 20:3, n-6,9,12 all-cis
  • 8,11,14-Eicosatrienoic Acid
  • 8c,11c,14c-eicosatrienoic acid
  • 8c,11c,14c-Eicosatriensaeure
  • all-cis-8,11,14-eicosatrienoic acid
  • all-cis-8,11,14-icosatrienoic acid
  • all-cis-eicosa-8,11,14-trienoic acid
  • all-cis-Eicosa-8,11,14-triensaeure
  • all-cis-icosa-8,11,14-trienoic acid
  • C20:3, n-6,9,12 all-cis
  • cis,cis,cis-8,11,14-eicosatrienoic acid
  • DGLA
  • Dihomo-gamma-linolenic acid
  • eicosa-8Z,11Z,14Z-trienoic acid
  • gamma-Homolinolenic acid
  • Homo-gamma-linolenic acid
  • Homo-gamma-linolensaeure
dietary supplements, micronutrients, supplements
Thuốc Gốc
Small Molecule
CAS: 1783-84-2
CTHH: C20H34O2
PTK: 306.4828
A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H34O2
Phân tử khối
306.4828
Monoisotopic mass
306.255880332
InChI
InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
InChI Key
InChIKey=HOBAELRKJCKHQD-QNEBEIHSSA-N
IUPAC Name
(8Z,11Z,14Z)-icosa-8,11,14-trienoic acid
Traditional IUPAC Name
gamma-homolinolenic acid
SMILES
CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O
Độ hòa tan
7.71e-05 g/l
logP
6.8
logS
-6.6
pKa (strongest acidic)
4.89
PSA
37.3 Å2
Refractivity
98.84 m3·mol-1
Polarizability
39.01 Å3
Rotatable Bond Count
15
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
0
Bioavailability
0
Dược Lực Học : Dihomo gamma-linolenic acid or DHLA is an n-6 (omega-6) polyunsaturated fatty acid. It is comprised of 20 carbon atoms and three double bonds. DHLA is a byproduct of the 18 carbon gamma-linolenic acid (GLA). DHLA is then converted into prostaglandin E1 (PGE1). PGE1 inhibits platelet aggregation and also exerts a vasodilatory effect.
Cơ Chế Tác Dụng : A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5. [PubChem] DHLA (or DGLA) is a precursor in the synthesis of prostaglandin E1 (PGE1) as well as the series-3 prostaglandins. It also serves as a precursor in the synthesis of eicosapentaenoic acid (EPA). EPA is a precursor of the series-3 prostaglandins, the series-5 leukotrienes and the series-3 thromboxanes. These eicosanoids have anti-thrombogenic, anti-inflammatory and anti-atherogenic properties. PGE1 inhibits platelet aggregation and has a vasodilation action. DHLA has also been shown to reduce the production/activity of tumor necrosis factor alpha.
Chỉ Định : For nutritional supplementation, also for treating dietary shortage or imbalance
Liều Lượng & Cách Dùng : Capsule - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : GNC
    Sản phẩm biệt dược : Star GLA
  • Công ty : Action Labs
    Sản phẩm biệt dược : Tona-lean 1000 CLA
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00154
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5280581
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508866
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C03242
ChemSpider
http://www.chemspider.com/Chemical-Structure.4444199.html
PharmGKB
http://www.pharmgkb.org/drug/PA164743249
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/gam_0120.shtml
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