Tìm theo
Diflorasone
Các tên gọi khác (4 ) :
  • (6alpha,11beta,16beta)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • (6α,11β,16β)-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • Diflorasona
  • Diflorasonum
anti inflammatory agents, glucocorticoids
Thuốc Gốc
Small Molecule
CAS: 2557-49-5
ATC: D07AC10
ĐG : Allergan Inc. , http://www.allergan.com
CTHH: C22H28F2O5
PTK: 410.4515
Diflorasone is a topical corticosteroid used to treat itching and inflammation of the skin.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H28F2O5
Phân tử khối
410.4515
Monoisotopic mass
410.190480416
InChI
InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1
InChI Key
InChIKey=WXURHACBFYSXBI-XHIJKXOTSA-N
IUPAC Name
(1R,2S,8S,10S,11S,13S,14R,15S,17S)-1,8-difluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
Traditional IUPAC Name
diflorasone
Độ hòa tan
8.53e-02 g/l
logP
2.1
logS
-3.7
pKa (strongest acidic)
12.42
pKa (Strongest Basic)
-3.3
PSA
94.83 Å2
Refractivity
102.32 m3·mol-1
Polarizability
40.95 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
5
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Like other topical corticosteroids, diflorasone has anti-inflammatory, antipruritic, and vasoconstrictive properties. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Diflorasone is a potent topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.
Cơ Chế Tác Dụng : Diflorasone is a topical corticosteroid used to treat itching and inflammation of the skin. The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Dược Động Học :
▧ Absorption :
Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.
▧ Protein binding :
Bound to plasma proteins in varying degrees.
▧ Metabolism :
Metabolized, primarily in the liver, and then excreted by the kidneys.
Độc Tính : Topically applied diflorasone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
Chỉ Định : For relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
Liều Lượng & Cách Dùng : Cream - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : ApexiCon
  • Công ty : Galderma
    Sản phẩm biệt dược : Florone
  • Công ty :
    Sản phẩm biệt dược : Florone E
  • Công ty :
    Sản phẩm biệt dược : Maxiflor
  • Công ty :
    Sản phẩm biệt dược : Psorcon
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