Tìm theo
Dienestrol
Các tên gọi khác (6 ) :
  • Dehydrostilbestrol
  • Dienestrol
  • Diènestrol
  • Dienestrol
  • Dienestrolum
  • DV
estrogens non steroidal
Thuốc Gốc
Small Molecule
CAS: 84-17-3
ATC: G03CB01, G03CC02
ĐG : Spectrum Pharmaceuticals , http://www.spectrumpharm.com
CTHH: C18H18O2
PTK: 266.3343
Dienestrol is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist. Estrogens work partly by increasing a normal clear discharge from the vagina and making the vulva and urethra healthy. Using or applying an estrogen relieves or lessens: dryness and soreness in the vagina, itching, redness, or soreness of the vulva. Conditions that are treated with vaginal estrogens include a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), and inflammation of the urethra (atrophic urethritis).
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H18O2
Phân tử khối
266.3343
Monoisotopic mass
266.13067982
InChI
InChI=1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3/b17-3+,18-4+
InChI Key
InChIKey=NFDFQCUYFHCNBW-SCGPFSFSSA-N
IUPAC Name
4-[4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol
Traditional IUPAC Name
dienestrol
SMILES
CC=C(C(=CC)C1=CC=C(O)C=C1)C1=CC=C(O)C=C1
Độ tan chảy
233-234
Độ hòa tan
3 mg/L (at 37 °C)
logP
5.9
logS
-4.95
pKa (strongest acidic)
9.1
pKa (Strongest Basic)
-6
PSA
40.46 Å2
Refractivity
84.36 m3·mol-1
Polarizability
30.3 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
Cơ Chế Tác Dụng : Dienestrol is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist. Estrogens work partly by increasing a normal clear discharge from the vagina and making the vulva and urethra healthy. Using or applying an estrogen relieves or lessens: dryness and soreness in the vagina, itching, redness, or soreness of the vulva. Conditions that are treated with vaginal estrogens include a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), and inflammation of the urethra (atrophic urethritis). Dienestrol is a synthetic, non-steroidal estrogen. Estrogens passively diffuse into target cells of responsive tissues, complex with the estrogen receptors, and enter the cell's nucleus to initiate or enhance gene transcription of protein synthesis after binding to DNA.
Dược Động Học :
▧ Absorption :
Systemic absorption and mode of action of dienestrol are undetermined.Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
▧ Protein binding :
50 to 80%
▧ Metabolism :
Hepatic.
Độc Tính : Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females.
Chỉ Định : For use in the treatment of atrophic vaginitis and kraurosis vulvae.
Liều Lượng & Cách Dùng : Cream - Intravaginal
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Dienestrol powder
    Giá bán buôn : USD >442.23
    Đơn vị tính : g
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00890
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08090
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00898
PharmGKB
http://www.pharmgkb.org/drug/PA164745534
Wikipedia
http://en.wikipedia.org/wiki/Dienestrol
RxList
http://www.rxlist.com/cgi/generic2/diene.htm
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