Tìm theo
Dicyclomine
Các tên gọi khác (7 ) :
  • 2-(Diethylamino)ethyl 1-cyclohexylcyclohexanecarboxylate
  • Bicyclohexyl-1-carboxylic acid 2-diethylamino-ethyl ester
  • Dicicloverina
  • DICYCLOMINE
  • Dicycloverin
  • Dicycloverine
  • Dicycloverinum
muscarinic antagonists, parasympatholytics, cholinergic antagonists, antispasmodics
Thuốc Gốc
Small Molecule
CAS: 77-19-0
ATC: A03AA07
ĐG : Advanced Pharmaceutical Services Inc.
CTHH: C19H35NO2
PTK: 309.4867
A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H35NO2
Phân tử khối
309.4867
Monoisotopic mass
309.266779369
InChI
InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
InChI Key
InChIKey=CURUTKGFNZGFSE-UHFFFAOYSA-N
IUPAC Name
2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate
Traditional IUPAC Name
dicyclomine
SMILES
CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
Độ tan chảy
165-166
Độ hòa tan
3.27e-03 g/l
logP
5.5
logS
-5
pKa (Strongest Basic)
8.96
PSA
29.54 Å2
Refractivity
91.78 m3·mol-1
Polarizability
37.39 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Dicyclomine is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Dicyclomine is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Dicyclomine inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.
Cơ Chế Tác Dụng : A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms. [PubChem] Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).
Dược Động Học :

▧ Volume of Distribution :
* 3.65 L/kg [20 mg oral dose]
▧ Protein binding :
>99%
▧ Route of Elimination :
The principal route of elimination is via the urine (79.5% of the dose). Excretion also occurs in the feces, but to a lesser extent (8.4%).
Chỉ Định : For the treatment of functional bowel/irritable bowel syndrome including Colicky abdominal pain; diverticulitis
Tương Tác Thuốc :
  • Donepezil Possible antagonism of action
  • Galantamine Possible antagonism of action
  • Haloperidol The anticholinergic increases the risk of psychosis and tardive dyskinesia
  • Rivastigmine Possible antagonism of action
  • Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Dicyclomine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
  • Trimethobenzamide Trimethobenzamide and Dicyclomine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
  • Triprolidine Triprolidine and Dicyclomine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
  • Trospium Trospium and Dicyclomine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Liều Lượng & Cách Dùng : Capsule - Oral
Solution - Intramuscular
Syrup - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Sanofi
    Sản phẩm biệt dược : Bentyl
  • Công ty : Axcan
    Sản phẩm biệt dược : Bentylol
  • Công ty :
    Sản phẩm biệt dược : Byclomine
  • Công ty :
    Sản phẩm biệt dược : Di-Spaz
  • Công ty :
    Sản phẩm biệt dược : Dibent
  • Công ty :
    Sản phẩm biệt dược : Dilomine
  • Công ty : Savage
    Sản phẩm biệt dược : Dyspas
  • Công ty : Sanofi
    Sản phẩm biệt dược : Merbentyl
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00804
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3042
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505371
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06951
ChemSpider
http://www.chemspider.com/Chemical-Structure.2934.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50010101
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0378-1610-01
PharmGKB
http://www.pharmgkb.org/drug/PA164744928
Wikipedia
http://en.wikipedia.org/wiki/Dicyclomine
RxList
http://www.rxlist.com/cgi/generic/dicyc.htm
Drugs.com
http://www.drugs.com/cdi/dicyclomine.html
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