Tìm theo
Diclofenamide
Các tên gọi khác (14 ) :
  • 1,3-disulfamoyl-4,5-dichlorobenzene
  • 1,3-Disulfamyl-4,5-dichlorobenzene
  • 3,4-Dichloro-5-sulfamylbenzenesulfonamide
  • 4,5-Dichloro-1,3-benzenedisulfonamide
  • 4,5-dichloro-1,3-disulfamoylbenzene
  • 4,5-Dichloro-benzene-1,3-disulfonic acid diamide
  • 4,5-dichloro-m-benzenedisulfonamide
  • 4,5-DICHLOROBENZENE-1,3-disulfonamide
  • Dichlofenamide
  • Dichlorophenamide
  • Dichlorphenamide
  • Diclofenamida
  • Diclofenamide
  • Diclofenamidum
carbonic anhydrase inhibitors, anti glaucoma agents, ophthalmics
Thuốc Gốc
Small Molecule
CAS: 120-97-8
ATC: S01EC02
CTHH: C6H6Cl2N2O4S2
PTK: 305.159
A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6H6Cl2N2O4S2
Phân tử khối
305.159
Monoisotopic mass
303.914603484
InChI
InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)
InChI Key
InChIKey=GJQPMPFPNINLKP-UHFFFAOYSA-N
IUPAC Name
4,5-dichlorobenzene-1,3-disulfonamide
Traditional IUPAC Name
dichlorphenamide
SMILES
NS(=O)(=O)C1=CC(=C(Cl)C(Cl)=C1)S(N)(=O)=O
Độ tan chảy
228.5
Độ hòa tan
3.98e-01 g/l
logP
0.2
logS
-2.9
pKa (strongest acidic)
7.94
PSA
120.32 Å2
Refractivity
59.98 m3·mol-1
Polarizability
25.04 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Dichlorphenamide is an oral carbonic anhydrase inhibitor indicated for adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure. Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow).
Cơ Chế Tác Dụng : A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. [PubChem] Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow), although the mechanism by which they do this is not fully understood. Evidence suggests that HCO3- ions are produced in the ciliary body by hydration of carbon dioxide under the influence of carbonic anhydrase and diffuse into the posterior chamber which contains more Na+ and HCO3- ions than does plasma and consequently is hypertonic. Water is then attracted to the posterior chamber by osmosis, resulting in a drop in pressure.
Dược Động Học :

▧ Protein binding :
55%
Chỉ Định : For adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure
Tương Tác Thuốc :
  • Acetylsalicylic acid Acetylsalicylic acid at high dose increases the effect of the carbonic anhydrase inhibitor, dichlorphenamide.
  • Brinzolamide As both brinzolamide and dichlorphenamide are carbonic anhydrase inhibitors, there is an increased risk of adverse effects.The development of acid-base disorders with concurrent use of ophthalmic and oral carbonic anhydrase inhibitors has been reported. Avoid concurrent use of different carbonic anhydrase inhibitors when possible.
  • Memantine Possible increased levels of memantine
  • Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Taro
    Sản phẩm biệt dược : Daranide
  • Công ty : Alcon
    Sản phẩm biệt dược : Oratrol
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01144
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3038
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505039
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07459
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00518
ChemSpider
http://www.chemspider.com/Chemical-Structure.2930.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10883
PharmGKB
http://www.pharmgkb.org/drug/PA164745512
Wikipedia
http://en.wikipedia.org/wiki/Dichlorphenamide
RxList
http://www.rxlist.com/cgi/generic/dichlorphen.htm
Drugs.com
http://www.drugs.com/mtm/dichlorphenamide.html
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