Tìm theo
Diatrizoate
Các tên gọi khác (17 ) :
  • 2,4,6-Triiodo-3,5-diacetamidobenzoic acid
  • 3,5-Bis(acetylamino)-2,4,6-triiodobenzoic acid
  • 3,5-diacetamido-2,4,6-triiodobenzoic acid
  • Acide amidotrizoique
  • Acidum amidotrizoicum
  • Acidum diacetylaminotrijodbenzoicum
  • Amidotrizoate
  • Amidotrizoic Acid
  • Amidotrizoic acid (anhydrous)
  • Diatrizoate
  • Diatrizoesaure
  • Diatrizoic acid
  • Diatrizoic acid (anhydrous)
  • Methalamic acid
  • Triombrin
  • Urografin acid
  • Urogranoic acid
contrast media
Thuốc Gốc
Small Molecule
CAS: 117-96-4
ATC: V08AA01, V08AA04
ĐG : Bayer Healthcare , http://www.bayerhealthcare.com
CTHH: C11H9I3N2O4
PTK: 613.9136
A commonly used x-ray contrast medium. As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H9I3N2O4
Phân tử khối
613.9136
Monoisotopic mass
613.769637046
InChI
InChI=1S/C11H9I3N2O4/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18/h1-2H3,(H,15,17)(H,16,18)(H,19,20)
InChI Key
InChIKey=YVPYQUNUQOZFHG-UHFFFAOYSA-N
IUPAC Name
3,5-diacetamido-2,4,6-triiodobenzoic acid
Traditional IUPAC Name
diatrizoate
SMILES
CC(=O)NC1=C(I)C(C(O)=O)=C(I)C(NC(C)=O)=C1I
Độ tan chảy
>250
Độ hòa tan
1.07e-01 g/l
logP
3.3
logS
-3.8
pKa (strongest acidic)
2.17
pKa (Strongest Basic)
-4.2
PSA
95.5 Å2
Refractivity
103.13 m3·mol-1
Polarizability
38.43 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
4
H Bond Donor Count
3
Physiological Charge
-1
Number of Rings
1
Bioavailability
1
Dược Lực Học : Diatrizoate is the most commonly used water-soluble, iodinated, radiopaque x-ray contrast medium. Radiopaque agents are drugs used to help diagnose certain medical problems. They contain iodine, which blocks x-rays. Depending on how the radiopaque agent is given, it localizes or builds up in certain areas of the body. The resulting high level of iodine allows the x-rays to make a "picture" of the area. The areas of the body in which the radiopaque agent localizes will appear white on the x-ray film. This creates the needed distinction, or contrast, between one organ and other tissues. The contrast will help the doctor see any special conditions that may exist in that organ or part of the body.
Cơ Chế Tác Dụng : A commonly used x-ray contrast medium. As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography. [PubChem] Diatrizoate is an iodine-containing X-ray contrast agent. Iodated contrast agents were among the first contrast agents developed. Iodine is known to be particular electron-dense and to effectively scatter or stop X-rays. A good contrast agent requires a high density of electron-dense atoms. Therefore, the more iodine, the more "dense" the x-ray effect. Iodine based contrast media are water soluble and harmless to the body. These contrast agents are sold as clear colorless water solutions, the concentration is usually expressed as mg I/ml. Modern iodinated contrast agents can be used almost anywhere in the body. Most often they are used intravenously, but for various purposes they can also be used intraarterially, intrathecally (the spine) and intraabdominally - just about any body cavity or potential space.
Dược Động Học :

▧ Route of Elimination :
However, it is not metabolized but excreted unchanged in the urine, each diatrizoate molecule remaining "obligated" to its sodium moiety. The liver and small intestine provide the major alternate route of excretion for diatrizoate. Injectable radiopaque diagnostic agents are excreted unchanged in human milk. Saliva is a minor secretory pathway for injectable radiopaque diagnostic agents.
Độc Tính : High osmolal radiocontrast agents like diatrizoate are cytotoxic to renal cells. The toxic effects include apoptosis, cellular energy failure, disruption of calcium homeostasis, and disturbance of tubular cell polarity, and are thought to be linked to oxidative stress.
Chỉ Định : Used, alone or in combination, for a wide variety of diagnostic imaging methods, including angiography, urography, cholangiography, computed tomography, hysterosalpingography, and retrograde pyelography. It can be used for imaging the gastrointestinal tract in patients allergic to barium.
Liều Lượng & Cách Dùng : Liquid - Intravenous
Powder - Oral
Solution - Intravenous
Solution - Urethral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Cardiografin
  • Công ty : Bayer
    Sản phẩm biệt dược : Gastrografin
  • Công ty : Amersham
    Sản phẩm biệt dược : Hypaque
  • Công ty :
    Sản phẩm biệt dược : MD-GASTROVIEW
  • Công ty :
    Sản phẩm biệt dược : Odiston
  • Công ty : Zydus
    Sản phẩm biệt dược : Urovison
  • Công ty : Bayer
    Sản phẩm biệt dược : Urovist
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00271
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2140
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504704
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01013
ChemSpider
http://www.chemspider.com/Chemical-Structure.2055.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0407-0766-04
PharmGKB
http://www.pharmgkb.org/drug/PA449281
Wikipedia
http://en.wikipedia.org/wiki/Diatrizoate
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