Tìm theo
Dextromoramide
Thuốc Gốc
Small Molecule
CAS: 357-56-2
CTHH: C25H32N2O2
PTK: 392.5338
An opioid analgesic structurally related to methadone and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C25H32N2O2
Phân tử khối
392.5338
Monoisotopic mass
392.246378278
InChI
InChI=1S/C25H32N2O2/c1-21(20-26-16-18-29-19-17-26)25(22-10-4-2-5-11-22,23-12-6-3-7-13-23)24(28)27-14-8-9-15-27/h2-7,10-13,21H,8-9,14-20H2,1H3
InChI Key
InChIKey=INUNXTSAACVKJS-UHFFFAOYSA-N
IUPAC Name
3-methyl-4-(morpholin-4-yl)-2,2-diphenyl-1-(pyrrolidin-1-yl)butan-1-one
Traditional IUPAC Name
dextromoramide
SMILES
CC(CN1CCOCC1)C(C(=O)N1CCCC1)(C1=CC=CC=C1)C1=CC=CC=C1
Độ tan chảy
182 °C
Độ hòa tan
1.75e-02 g/l
logP
3.61
logS
-4.3
pKa (Strongest Basic)
7.77
PSA
32.78 Å2
Refractivity
117.37 m3·mol-1
Polarizability
44.84 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Tương Tác Thuốc :
  • Alvimopan Increases levels by receptor binding competition. Discontinue opioid administration at least 7 days prior to administrating Alvimopan.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01529
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=9648
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507896
ChemSpider
http://www.chemspider.com/Chemical-Structure.9269.html
Wikipedia
http://en.wikipedia.org/wiki/Dextromoramide
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