Tìm theo
Dexbrompheniramine
Các tên gọi khác (13 ) :
  • (+)-Brompheniraminum
  • (+)-parabromdylamine
  • (R)-3-(4-Bromophenyl)-3-(2-pyridyl)propyldimethylamine
  • (S)-(+)-Brompheniramine
  • (S)-Brompheniramine
  • 3-(4-bromophenyl)- N,N-dimethyl- 3-pyridin-2-yl-propan-1-amine
  • D-Brompheniramine
  • Desbrofeniramina
  • Dexbromfeniramina
  • Dexbrompheniramin
  • Dexbromphéniramine
  • Dexbrompheniraminum
  • Parabromodylamine
histamine h1 antagonists, histamine antagonists
Thuốc Gốc
Small Molecule
CAS: 132-21-8
ATC: R06AB06
ĐG : Poly Pharmaceuticals Inc. , http://www.polypharmaceuticals.net
CTHH: C16H19BrN2
PTK: 319.239
Dexbrompheniramine maleate is an antihistamine used to treat allergic conditions such as hay fever or urticaria.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H19BrN2
Phân tử khối
319.239
Monoisotopic mass
318.073161265
InChI
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1
InChI Key
InChIKey=ZDIGNSYAACHWNL-HNNXBMFYSA-N
IUPAC Name
[(3S)-3-(4-bromophenyl)-3-(pyridin-2-yl)propyl]dimethylamine
Traditional IUPAC Name
dexbrompheniramine
SMILES
CN(C)CC[C@@H](C1=CC=C(Br)C=C1)C1=CC=CC=N1
Độ tan chảy
113-115
Độ hòa tan
1.27e-02 g/l
logP
3.4
logS
-4.4
pKa (Strongest Basic)
9.48
PSA
16.13 Å2
Refractivity
83.67 m3·mol-1
Polarizability
31.84 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Dexbrompheniramine is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Cơ Chế Tác Dụng : Dexbrompheniramine maleate is an antihistamine used to treat allergic conditions such as hay fever or urticaria. Dexbrompheniramine competitively binds to the histamine H1-receptor. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Dược Động Học :
▧ Absorption :
Antihistamines are well absorbed from the gastrointestinal tract after oral administration.
▧ Metabolism :
Hepatic (cytochrome P-450 system), some renal.
▧ Half Life :
25 hours
Độc Tính : Signs of an overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.
Chỉ Định : For treatment and relief of symptoms of allergies, hay fever, and colds
Tương Tác Thuốc :
  • Donepezil Possible antagonism of action
  • Galantamine Possible antagonism of action
  • Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Dexbrompheniramine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
  • Trimethobenzamide Trimethobenzamide and Dexbrompheniramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
  • Triprolidine Triprolidine and Dexbrompheniramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
  • Trospium Trospium and Dexbrompheniramine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Schering
    Sản phẩm biệt dược : Disophrol
  • Công ty : Schering
    Sản phẩm biệt dược : Drixoral
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00405
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=16960
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505186
ChemSpider
http://www.chemspider.com/Chemical-Structure.16068.html
PharmGKB
http://www.pharmgkb.org/drug/PA164746251
Wikipedia
http://en.wikipedia.org/wiki/Dexbrompheniramine
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