Tìm theo
Desoxycorticosterone Pivalate
Các tên gọi khác (9 ) :
  • Deoxycorticosterone Pivalate
  • Deoxycorticosterone Trimethylacetate
  • Deoxycortolone Pivalate
  • Deoxycortone Pivalate
  • Deoxycortone Trimethylacetate
  • Desoxycorticosterone Trimethylacetate
  • Desoxycortone Pivalate
  • DOCP
  • DTMA
Thuốc Gốc
Small Molecule
CAS: 808-48-0
ĐG : Baxter International Inc. , http://www.baxter.com
CTHH: C26H38O4
PTK: 414.5775
Desoxycorticosterone Pivalate is a mineralocorticoid hormone and an analog of desoxycorticosterone. It is white, odorless, and stable in air. It is practically insoluble in water, sparingly soluble in acetone, slightly soluble in methanol, ether and vegetable oils. Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C26H38O4
Phân tử khối
414.5775
Monoisotopic mass
414.277009704
InChI
InChI=1S/C26H38O4/c1-24(2,3)23(29)30-15-22(28)21-9-8-19-18-7-6-16-14-17(27)10-12-25(16,4)20(18)11-13-26(19,21)5/h14,18-21H,6-13,15H2,1-5H3
InChI Key
InChIKey=VVOIQBFMTVCINR-UHFFFAOYSA-N
IUPAC Name
2-{2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl}-2-oxoethyl 2,2-dimethylpropanoate
Traditional IUPAC Name
2-{2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl}-2-oxoethyl 2,2-dimethylpropanoate
SMILES
CC(C)(C)C(=O)OCC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C
Độ hòa tan
Insoluble
logP
4
logS
-5.5
pKa (strongest acidic)
17.19
pKa (Strongest Basic)
-4.8
PSA
60.44 Å2
Refractivity
117.26 m3·mol-1
Polarizability
48.32 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Ghose Filter
true
Dược Lực Học : Used to treat adrenocortical insufficiency, desoxycorticosterone pivalate is a mineralocorticoid hormone and an analogue of desoxycorticosterone. It primarily acts on the metabolism of sodium, potassium and water. When the drug is given, there is decreased excretion of sodium accompanied by increased excretion of potassium; the concentration of sodium in the blood is thereby increased whereas that of potassium is decreased. There is a concomitant increase in the volume of blood and extracellular fluids, with a fall in hematocrit. It increases the rate of renal tubular absorption of sodium.
Cơ Chế Tác Dụng : Desoxycorticosterone Pivalate is a mineralocorticoid hormone and an analog of desoxycorticosterone. It is white, odorless, and stable in air. It is practically insoluble in water, sparingly soluble in acetone, slightly soluble in methanol, ether and vegetable oils. Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian. Desoxycorticosterone Pivalate binds to the mineralocorticoid receptor. Mineralocorticoids are a family of steroids, secreted by the adrenal cortex, necessary for the regulation of a number of metabolic processes including electrolyte regulation. Desoxycorticosterone pivalate exerts its effect through its interaction with the mineralocorticoid receptor (MR), whereby it reacts with the receptor proteins to form a steroid-receptor complex. This complex moves into the nucleus, where it binds to chromatin which results in genetic transcription of cellular DNA to messenger RNA. The steroid hormones appear to induce transcription and synthesis of specific proteins, which produce the physiological effects seen after administration.
Dược Động Học :

▧ Protein binding :
90%
Độc Tính : Symptoms of overdose include polyuria, polydipsia, increased blood volume, edema, and cardiac enlargement.
Chỉ Định : Examined for treatment of adrenocortical insufficiency especially in multiple sclerosis, congenital cerebral palsy, polyarteritis nodosa, and rheumatoid arthritis. Currently only approved in treating cats and dogs for the treatment of Addison's disease.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Cortexone M
  • Công ty :
    Sản phẩm biệt dược : Neodin-Depositum
  • Công ty :
    Sản phẩm biệt dược : Percorten
  • Công ty :
    Sản phẩm biệt dược : Percorten M
  • Công ty :
    Sản phẩm biệt dược : Percorten Pivalate
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01134
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=13126
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506381
ChemSpider
http://www.chemspider.com/Chemical-Structure.12574.html
PharmGKB
http://www.pharmgkb.org/drug/PA449245
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