Tìm theo
Desonide
Các tên gọi khác (9 ) :
  • 11beta,21-Dihydroxy-16alpha,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
  • 11beta,21-Dihydroxy-16alpha,17-isopropylidenedioxypregna-1,4-diene-3,20-dione
  • 11beta,21-Dihydroxy-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione
  • 16alpha-Hydroxyprednisole-16,17-acetonide
  • 16alpha-Hydroxyprednisolone-16alpha,17-acetonide
  • 16alpha,17alpha-Isopropylidenedioxyprednisolone
  • Desfluorotriamcinolone acetonide
  • Desonida
  • Desonidum
Thuốc điều trị bệnh da liễu
Thuốc Gốc
Small Molecule
CAS: 638-94-8
ATC: S01BA11, D07AB08
ĐG : Actavis Group , http://www.actavis.com
CTHH: C24H32O6
PTK: 416.5073
A nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C24H32O6
Phân tử khối
416.5073
Monoisotopic mass
416.219888756
InChI
InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1
InChI Key
InChIKey=WBGKWQHBNHJJPZ-LECWWXJVSA-N
IUPAC Name
(1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one
Traditional IUPAC Name
desonide
SMILES
[H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(=O)CO
Độ tan chảy
257-260
Độ hòa tan
Practically insoluble
logP
1.4
logS
-3.9
pKa (strongest acidic)
13.74
pKa (Strongest Basic)
-2.9
PSA
93.06 Å2
Refractivity
112.06 m3·mol-1
Polarizability
44.77 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
6
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
5
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Desonide is a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents.
Cơ Chế Tác Dụng : A nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses. [PubChem] Like other topical corticosteroids, desonide has anti-inflammatory, antipruritic and vasoconstrictive properties. The drug binds to cytosolic glucocorticoid receptors. This complex migrates to the nucleus and binds to genetic elements on the DNA. This activates and represses various genes. However corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Dược Động Học :
▧ Absorption :
Topical corticosteroids can be absorbed from normal intact skin, inflammation and/or other disease processes in the skin may increase percutaneous absorption.
Chỉ Định : For the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatose.
Liều Lượng & Cách Dùng : Cream - Topical
Lotion - Topical
Ointment - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Galderma
    Sản phẩm biệt dược : Desocort
  • Công ty :
    Sản phẩm biệt dược : Desonate
  • Công ty : Galderma
    Sản phẩm biệt dược : Desowen
  • Công ty :
    Sản phẩm biệt dược : LoKara
  • Công ty : Bayer
    Sản phẩm biệt dược : Tridesilon
  • Công ty :
    Sản phẩm biệt dược : Verdeso
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01260
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5311066
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506186
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D03696
ChemSpider
http://www.chemspider.com/Chemical-Structure.4470603.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0299-5770-60
PharmGKB
http://www.pharmgkb.org/drug/PA164776996
Wikipedia
http://en.wikipedia.org/wiki/Desonide
RxList
http://www.rxlist.com/cgi/generic/desonide.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/tri1457.shtml
Drugs.com
http://www.drugs.com/cdi/desonide-cream.html
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