Tìm theo
Desflurane
Các tên gọi khác (7 ) :
  • (+-)-2-Difluoromethyl 1,2,2,2-tetrafluoroethyl ether
  • 1,1,1,2-Tetrafluoro-2-(difluoromethoxy)ethane
  • Desflurane
  • Desflurano
  • Desfluranum
  • Difluoromethyl 1,2,2,2-tetrafluoroethyl ether
  • Suprane
anesthetics inhalation
Thuốc Gốc
Small Molecule
CAS: 57041-67-5
ATC: N01AB07
ĐG : Baxter International Inc. , http://www.baxter.com
CTHH: C3H2F6O
PTK: 168.0378
Desflurane is a highly fluorinated methyl ethyl ether used for maintenance of general anaesthesia. Volatile agents such as desflurane may activate GABA channels and hyperpolarize cell membranes. In addition, they may inhibit certain calcium channels and therefore prevent release of neurotransmitters and inhibit glutamate channels. Volatile anesthetics easily partition into cellular membranes and could expand the volume of the cell membrane and subsequently distort channels necessary for sodium ion flux and the development of action potentials necessary for synaptic transmission. Desflurane preconditions human myocardium against ischemia through activation of mitochondrial K(ATP) channels, adenosine A1 receptor, and alpha and beta adrenoceptors.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C3H2F6O
Phân tử khối
168.0378
Monoisotopic mass
168.000983916
InChI
InChI=1S/C3H2F6O/c4-1(3(7,8)9)10-2(5)6/h1-2H
InChI Key
InChIKey=DPYMFVXJLLWWEU-UHFFFAOYSA-N
IUPAC Name
2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane
Traditional IUPAC Name
desflurane
SMILES
FC(F)OC(F)C(F)(F)F
Độ sôi
23.5 °C
Độ hòa tan
Negligible
logP
1.9
logS
-1.7
pKa (strongest acidic)
18.87
pKa (Strongest Basic)
-4.8
PSA
9.23 Å2
Refractivity
18.12 m3·mol-1
Polarizability
7.89 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Desflurane is a general inhalation anesthetic. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Cơ Chế Tác Dụng : Desflurane is a highly fluorinated methyl ethyl ether used for maintenance of general anaesthesia. Volatile agents such as desflurane may activate GABA channels and hyperpolarize cell membranes. In addition, they may inhibit certain calcium channels and therefore prevent release of neurotransmitters and inhibit glutamate channels. Volatile anesthetics easily partition into cellular membranes and could expand the volume of the cell membrane and subsequently distort channels necessary for sodium ion flux and the development of action potentials necessary for synaptic transmission. Desflurane preconditions human myocardium against ischemia through activation of mitochondrial K(ATP) channels, adenosine A1 receptor, and alpha and beta adrenoceptors. Desflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Desflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Desflurane also binds to and agonizes the GABA receptor, the large conductance Ca2+ activated potassium channel, the glycine receptors, and antagonizes the glutamate receptors.
Dược Động Học :
▧ Absorption :
Rapidly absorbed into the circulation via the lungs following inhalation.
▧ Metabolism :
Minimally biotransformed in the liver in humans (approximately 0.02% of the quantity absorbed).
Chỉ Định : For use as an inhalation agent for induction and/or maintenance of anesthesia for inpatient and outpatient surgery in adults.
Liều Lượng & Cách Dùng : Liquid - Respiratory (inhalation)
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Suprane
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01189
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=42113
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505270
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07519
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00546
ChemSpider
http://www.chemspider.com/Chemical-Structure.38403.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/10019-641-24
PharmGKB
http://www.pharmgkb.org/drug/PA164749136
Wikipedia
http://en.wikipedia.org/wiki/Desflurane
RxList
http://www.rxlist.com/cgi/generic2/desflurane.htm
Drugs.com
http://www.drugs.com/cons/desflurane-inhalation-oral-nebulization.html
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