Tìm theo
Denileukin diftitox
Các tên gọi khác (3) :
  • Diphtheria toxin precursor
  • DT
  • NAD(+--diphthamide ADP- ribosyltransferase)
Thuốc điều trị ung thư
Thuốc Gốc
Biotech
CAS: 173146-27-5
ATC: L01XX29
ĐG : Eisai Inc. , http://www.eisai.com
CTHH: C2560H4042N678O799S17
PTK: 57647.3000
A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C2560H4042N678O799S17
Phân tử khối
57647.3000
Độ kỵ nước
-0.301
Điểm đẳng điện tích
5.45
Dược Lực Học : Denileukin diftitox (Ontak) directs the cytocidal action of diphtheria toxin to cells which express the IL-2 receptor. The human IL-2 receptor exists in three forms, low (CD25), intermediate (CD122/CD132) and high (CD25/CD122/CD132) affinity. Malignant cells expressing one or more of the subunits of the IL-2 receptor are found in certain leukemias and lymphomas including cutaneous T-cell lymphoma (CTCL). Ontak interacts with the high affinity IL-2 receptor on the cell surface and inhibits cellular protein synthesis, resulting in cell death within hours.
Cơ Chế Tác Dụng : A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. Denileukin diftitox binds to the high-affinity IL-2 receptor complex. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes. The diphtheria toxin associated with Ontak then selectively kills the IL-2 bearing cells.
Dược Động Học :

▧ Volume of Distribution :
* 0.06 to 0.09 L/kg
▧ Half Life :
70-80 min
▧ Clearance :
* 0.6 - 2.0 mL/min/kg [Lymphoma]
Chỉ Định : For treatment of cutaneous T-cell lymphoma
Tương Tác Thuốc :
  • Rilonacept decreases effects of toxoids by pharmacodynamic antagonism.
  • Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Liều Lượng & Cách Dùng : Solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Ontak 150 mcg/ml vial
    Giá bán buôn : USD >878.4
    Đơn vị tính : ml
Nhà Sản Xuất
  • Công ty : Seragen Inc
    Sản phẩm biệt dược : Ontak
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00004
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/62856-603-01
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/V01536
PharmGKB
http://www.pharmgkb.org/drug/PA164750594
Wikipedia
http://en.wikipedia.org/wiki/Denileukin_diftitox
RxList
http://www.rxlist.com/cgi/generic2/denileukin.htm
Drugs.com
http://www.drugs.com/cdi/denileukin-diftitox.html
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