Tìm theo
Delta1-dihydrotestosterone
Các tên gọi khác (4 ) :
  • 1-T
  • 1-Testo
  • 1-testosterone
  • 17beta-hydroxy-5alpha-androst-1-en-3-one
Thuốc Gốc
Small Molecule
CAS: 65-06-5
CTHH: C19H28O2
PTK: 288.4244
Delta1-dihydrotestosterone is an anabolic steroid that differs from testosterone by having a 1,2-double bond instead of 4,5-double bond in its A ring. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H28O2
Phân tử khối
288.4244
Monoisotopic mass
288.20893014
InChI
InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h7,9,12,14-17,21H,3-6,8,10-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1
InChI Key
InChIKey=OKJCFMUGMSVJBG-ABEVXSGRSA-N
IUPAC Name
(1S,2R,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-en-5-one
Traditional IUPAC Name
1-testosterone
SMILES
[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)C=C[C@]12C
Độ hòa tan
1.28e-02 g/l
logP
3.41
logS
-4.3
pKa (strongest acidic)
19.38
pKa (Strongest Basic)
-0.88
PSA
37.3 Å2
Refractivity
84.7 m3·mol-1
Polarizability
34.06 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Delta1-dihydrotestosterone binds to the androgen receptor, a nuclear receptor which binds the androgenic hormones testosterone and dihydrotestosterone. Once bound, the receptor/ligand complex localizes to the nucleus and acts as a DNA binding transcription factor, regulating gene expression. In animals, Delta1-dihydrotestosterone stimulates the growth of the prostate as well as the seminal vesicles.
Cơ Chế Tác Dụng : Delta1-dihydrotestosterone is an anabolic steroid that differs from testosterone by having a 1,2-double bond instead of 4,5-double bond in its A ring. [Wikipedia] Delta1-dihydrotestosterone binds to the androgen receptor, a nuclear receptor which binds the androgenic hormones testosterone and dihydrotestosterone. Once bound, the receptor/ligand complex localizes to the nucleus and acts as a DNA binding transcription factor, regulating gene expression.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01481
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=236666
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507716
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C15377
ChemSpider
http://www.chemspider.com/Chemical-Structure.206590.html
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