Tìm theo
Decamethonium
Các tên gọi khác (5 ) :
  • Decamethonium
  • DECAMETHONIUM ion
  • Decamethonum
  • Decamethylenebis(trimethylammonium)
  • N,N,N,N',n',n'-hexamethyl-1,10-decanediaminium
neuromuscular depolarizing agents
Thuốc Gốc
Small Molecule
CAS: 156-74-1
CTHH: C16H38N2
PTK: 258.4863
Decamethonium is a short acting depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. It is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H38N2
Phân tử khối
258.4863
Monoisotopic mass
258.303499226
InChI
InChI=1S/C16H38N2/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6/h7-16H2,1-6H3/q+2
InChI Key
InChIKey=MTCUAOILFDZKCO-UHFFFAOYSA-N
IUPAC Name
trimethyl[10-(trimethylazaniumyl)decyl]azanium
Traditional IUPAC Name
decamethonium
SMILES
C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C
Độ tan chảy
268-270 °C
Độ hòa tan
Substantial
logP
-4.9
logS
-7.7
Refractivity
106.95 m3·mol-1
Polarizability
35.94 Å3
Polar Surface Area (PSA)
0
Rotatable Bond Count
11
H Bond Acceptor Count
0
H Bond Donor Count
0
Physiological Charge
2
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Decamethonium acts as a depolarizing muscle relaxant or neuromuscular blocking agent. It acts as an agonist of nicotinic acetycholine receptors in the motor endplate and causes depolarization. This class of drugs has its effect at the neuromuscular junction by preventing the effects of acetylcholine. Normally, when a nerve stimulus acts to contract a muscle, it releases acetylcholine. The binding of this acetylcholine to receptors causes the muscle to contract. Muscle relaxants play an important role in anesthesia even though they don't provide any pain relief or produce unconsciousness.
Cơ Chế Tác Dụng : Decamethonium is a short acting depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. It is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. Binds to the nicotinic acetycholine receptors (by virtue of its similarity to acetylcholine) in the motor endplate and blocks access to the receptors. In the process of binding, the receptor is actually activated - causing a process known as depolarization. Since it is not degraded in the neuromuscular junction, the depolarized membrance remains depolarized and unresponsive to any other impulse, causing muscle paralysis.
Dược Động Học :
▧ Absorption :
Rapidly absorbed.
Độc Tính : LD50=190 mg/kg (orally in mice). Prolonged apnoea, neuromuscular paralysis and cardiac arrest may occur.
Chỉ Định : For use as a skeletal muscle relaxant
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Syncurine
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01245
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2968
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507737
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C11733
ChemSpider
http://www.chemspider.com/Chemical-Structure.2862.html
PharmGKB
http://www.pharmgkb.org/drug/PA164747980
Wikipedia
http://en.wikipedia.org/wiki/Decamethonium
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