Tìm theo
Dalfopristin
Các tên gọi khác (3) :
  • Dalfopristina
  • Dalfopristine
  • Dalfopristinum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 112362-50-2
CTHH: C34H50N4O9S
PTK: 690.847
Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C34H50N4O9S
Phân tử khối
690.847
Monoisotopic mass
690.329849908
InChI
InChI=1S/C34H50N4O9S/c1-7-37(8-2)16-17-48(44,45)28-13-15-38-31(28)34(43)47-32(22(3)4)24(6)11-12-29(41)35-14-9-10-23(5)18-25(39)19-26(40)20-30-36-27(21-46-30)33(38)42/h9-12,18,21-22,24-25,28,31-32,39H,7-8,13-17,19-20H2,1-6H3,(H,35,41)/b10-9-,12-11-,23-18-/t24-,25-,28-,31?,32-/m1/s1
InChI Key
InChIKey=SUYRLXYYZQTJHF-FUODUHIRSA-N
IUPAC Name
(6R,10R,11R,21S)-6-{[2-(diethylamino)ethane]sulfonyl}-21-hydroxy-11,19-dimethyl-10-(propan-2-yl)-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.0^{3,7}]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetrone
Traditional IUPAC Name
(6R,10R,11R,21S)-6-[2-(diethylamino)ethanesulfonyl]-21-hydroxy-10-isopropyl-11,19-dimethyl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.0^{3,7}]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetrone
SMILES
CCN(CC)CCS(=O)(=O)[C@]1([H])CCN2C(=O)C3=COC(=N3)CC(=O)C[C@H](O)\C=C(\C)/C=C\CNC(=O)\C=C/[C@@H](C)[C@@H](C(C)C)OC(=O)C12
Độ hòa tan
7.16e-02 g/l
logP
1.58
logS
-4
pKa (strongest acidic)
11.38
pKa (Strongest Basic)
7.09
PSA
176.42 Å2
Refractivity
182.84 m3·mol-1
Polarizability
73.8 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
9
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
3
Bioavailability
1
MDDR-Like Rule
true
Dược Lực Học : Dalfopristin is a streptogramin antibiotic, derived from pristinamycin IIA.
Cơ Chế Tác Dụng : Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis. The site of action of dalfopristin is the bacterial ribosome. Dalfopristin has been shown to inhibit the early phase of protein synthesis.
Dược Động Học :

▧ Protein binding :
Moderate
▧ Metabolism :
Converted to an active non-conjugated metabolite by hydrolysis.
▧ Half Life :
The elimination half-life is approximately 0.70 hours.
Chỉ Định : For the treatment of bacterial infections (usually in combination with quinupristin).
Liều Lượng & Cách Dùng : Solution - Intravenous
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01764
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=21943991
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506561
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08033
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00853
ChemSpider
http://www.chemspider.com/Chemical-Structure.4940480.html
PharmGKB
http://www.pharmgkb.org/drug/PA164746234
Wikipedia
http://en.wikipedia.org/wiki/Dalfopristin
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