Tìm theo
Cysteamine
Các tên gọi khác (15 ) :
  • 2-Amino-1-ethanethiol
  • 2-AMINO-ethanethiol
  • 2-Aminoethanethiol
  • beta-Aminoethanethiol
  • beta-Aminoethylthiol
  • beta-MEA
  • beta-Mercaptoethylamine
  • Cysteamine
  • MEA
  • Mercaptamina
  • Mercaptamine
  • Mercaptaminum
  • Thioethanolamine
  • β-aminoethylthiol
  • β-MEA
radiation protective agents, ophthalmics
Thuốc Gốc
Small Molecule
CAS: 60-23-1
ATC: A16AA04
ĐG : Mylan , http://www.mylan.com
CTHH: C2H7NS
PTK: 77.149
Cysteamine is a radiation-protective agent that oxidizes in air to form cystamine. It can be given intravenously or orally to treat radiation sickness. The bitartrate and hydrochloride salt forms are indicated for the treatment of neuropathic cystinosis in patients 6 years old and older. [PubChem]. Cysteamine is marketed under several brand names such as Cystaran™, Procysbi, and Cystagon®.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C2H7NS
Phân tử khối
77.149
Monoisotopic mass
77.029919919
InChI
InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2
InChI Key
InChIKey=UFULAYFCSOUIOV-UHFFFAOYSA-N
IUPAC Name
2-aminoethane-1-thiol
Traditional IUPAC Name
cysteamine
SMILES
NCCS
Độ tan chảy
98 °C
Độ hòa tan
Freely soluble in water.
logP
0.1
logS
-0.52
pKa (strongest acidic)
9.42
pKa (Strongest Basic)
10.4
PSA
26.02 Å2
Refractivity
22.39 m3·mol-1
Polarizability
8.65 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
1
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : People born without the ability to metabolize the amino acid cystine suffer from cystinosis, a rare inherited disorder characterized by the deposition and accumulation of cystine crystals throughout the body. These crystals cause considerable damage, particularly in the kidney and eye. Kidney failure can occur by the age of 10 in untreated patients. Cysteamine prevents the accumulation of cystine crystals and is prescribed to prevent further kidney and eye damage. Cysteamine helps to convert cystine into less harmful chemical forms that can be removed from cells.
Cơ Chế Tác Dụng : Cysteamine is a radiation-protective agent that oxidizes in air to form cystamine. It can be given intravenously or orally to treat radiation sickness. The bitartrate and hydrochloride salt forms are indicated for the treatment of neuropathic cystinosis in patients 6 years old and older. [PubChem]. Cysteamine is marketed under several brand names such as Cystaran™, Procysbi, and Cystagon®. The free thiol cysteamine depletes cystinotic leukocytes and other cells of cystine, whose accumulation is considered the cause of organ damage in cystinosis. Cysteamine cleaves the disulfide bond with cystine to produce molecules that can escape the metabolic defect in cystinosis and cystinuria.
Dược Động Học :
▧ Absorption :
Cystagon® reaches its maximum plasma concentration in about 1.4 hours.
▧ Volume of Distribution :
Cystagon® has a volume of distribution of 156 L.
▧ Protein binding :
Cysteamine has a plasma protein binding of 52% and is mostly bound to albumin.
▧ Metabolism :
The metabolism of cysteamine has not yet been determined.
▧ Clearance :
The plasma clearance is about 1.2 L/min.
Độc Tính : Symptoms of overdose may include convulsions (seizures), increased thirst and unusual tiredness or weakness.
Chỉ Định : Given intravenously or orally to treat radiation sickness. The bitartrate salts (Cystagon® and Procysbi) have been used for the oral treatment of nephropathic cystinosis and cystinurea. The hydrochloride salt (Cystaran™) is indicated for the treatment of corneal cystine crystal accumulation in cystinosis patients.
Liều Lượng & Cách Dùng : Capsule - Oral - EQ 150MG BASE (CYSTAGON)
Capsule - Oral - EQ 50MG BASE (CYSTAGON )
Capsule, delayed release - Oral - 25MG BASE (PROCYSBI)
Capsule, delayed release - Oral - 75MG BASE (PROCYSBI)
Solution / drops - Ophthalmic - EQ 0.44% BASE (CYSTARAN)
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Mylan
    Sản phẩm biệt dược : Cystagon
  • Công ty : Sigma Tau
    Sản phẩm biệt dược : Cystaran
  • Công ty : Raptor Pharms
    Sản phẩm biệt dược : Procysbi
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00847
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6058
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507730
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C01678
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D03634
ChemSpider
http://www.chemspider.com/Chemical-Structure.5834.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7968
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0378-9040-05
PharmGKB
http://www.pharmgkb.org/drug/PA449171
Wikipedia
http://en.wikipedia.org/wiki/Cysteamine
RxList
http://www.rxlist.com/cystagon-drug.htm
Drugs.com
http://www.drugs.com/cdi/cysteamine.html
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