Tìm theo
Cycrimine
Các tên gọi khác (4 ) :
  • (+-)-Cycrimine
  • alpha-Cyclopentyl-alpha-phenyl-1-piperidinepropanol
  • Cicrimina
  • Cycriminum
antidyskinetics
Thuốc Gốc
Small Molecule
CAS: 77-39-4
CTHH: C19H29NO
PTK: 287.4397
Cycrimine is a drug used to reduce levels of acetylcholine to return a balance with dopamine in the treatment and management of Parkinson's disease.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H29NO
Phân tử khối
287.4397
Monoisotopic mass
287.224914555
InChI
InChI=1S/C19H29NO/c21-19(18-11-5-6-12-18,17-9-3-1-4-10-17)13-16-20-14-7-2-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2
InChI Key
InChIKey=SWRUZBWLEWHWRI-UHFFFAOYSA-N
IUPAC Name
1-cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol
Traditional IUPAC Name
cycrimine
SMILES
OC(CCN1CCCCC1)(C1CCCC1)C1=CC=CC=C1
Độ tan chảy
112-113
Độ hòa tan
9.09e-03 g/l
logP
4
logS
-4.5
pKa (strongest acidic)
13.84
pKa (Strongest Basic)
9.32
PSA
23.47 Å2
Refractivity
88.6 m3·mol-1
Polarizability
34.78 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Cycrimine is a central anticholenergic used in the treatment of the symptoms of Parkinson's disease. It is a drug used to reduce levels of acetylcholine. Acetylcholine is usually in balance with dopamine neurotransmitters, however lower levels of dopamine are present in the brain of patients suffering from Parkinson's disease. By lowering levels of acetylcholine, it is thought that this balance may be restored.
Cơ Chế Tác Dụng : Cycrimine is a drug used to reduce levels of acetylcholine to return a balance with dopamine in the treatment and management of Parkinson's disease. Cycrimine binds the muscarinic acetylcholine receptor M1, effectively inhibiting acetylcholine. This decrease in acetylcholine restores the normal dopamine-acetylcholine balance and relieves the symptoms of Parkinson's disease.
Dược Động Học :

▧ Protein binding :
14-21%
Chỉ Định : For treatment and management of Parkinson's disease.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Lilly
    Sản phẩm biệt dược : Pagitane
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00942
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2911
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506736
ChemSpider
http://www.chemspider.com/Chemical-Structure.2808.html
PharmGKB
http://www.pharmgkb.org/drug/PA164749387
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