Tìm theo
Cycloleucine
Các tên gọi khác (8 ) :
  • 1-Amino-1-cyclopentanecarboxylic acid
  • 1-Amino-cyclopentanecarboxylic acid
  • 1-Aminocyclopentane-1-carboxylic acid
  • 1-Aminocyclopentanecarboxylate
  • 1-Aminocyclopentanecarboxylic acid
  • Amino-1-cyclopentanecarboxylic acid
  • Cyclo-leucine
  • Cycloleucin
Thuốc Gốc
Small Molecule
CAS: 52-52-8
CTHH: C6H11NO2
PTK: 129.157
Cycloleucine is an amino acid formed by cyclization of leucine. Cycloleucine is a non-metabolisable amino acid and is a specific and reversible inhibitor of nucleic acid methylation, and as such is widely used in biochemical experiments. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6H11NO2
Phân tử khối
129.157
Monoisotopic mass
129.078978601
InChI
InChI=1S/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9)
InChI Key
InChIKey=NILQLFBWTXNUOE-UHFFFAOYSA-N
IUPAC Name
1-aminocyclopentane-1-carboxylic acid
Traditional IUPAC Name
cycloleucine
SMILES
NC1(CCCC1)C(O)=O
Độ tan chảy
330 dec °C
Độ hòa tan
5E+004 mg/L (at 25 °C)
logP
-2.28
logS
0.12
pKa (strongest acidic)
2.48
pKa (Strongest Basic)
9.83
PSA
63.32 Å2
Refractivity
32.46 m3·mol-1
Polarizability
13.23 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
pKa
2.62
Dược Lực Học : Cycloleucine has cytostatic, immunosuppressive and antineoplastic activities.
Độc Tính : Oral, mouse: LD50 = 309 mg/kg; oral, rat: LD50 = 290 mg/kg
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04620
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2901
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505671
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C03969
Wikipedia
http://en.wikipedia.org/wiki/Cycloleucine
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