Tìm theo
Cyanocobalamin
Các tên gọi khác (3) :
  • Cyanocob(III)alamin
  • Vitamin B12
  • Vitamin B12 complex
Khoáng chất và Vitamin
Thuốc Gốc
Small Molecule
CAS: 68-19-9
ATC: B03BB01, B03BA01
ĐG : American Regent , http://www.americanregent.com
CTHH: C63H89CoN14O14P
PTK: 1356.3731
Cyanocobalamin (commonly known as Vitamin B12) is the most chemically complex of all the vitamins. Cyanocobalamin's structure is based on a corrin ring, which, although similar to the porphyrin ring found in heme, chlorophyll, and cytochrome, has two of the pyrrole rings directly bonded. The central metal ion is Co (cobalt). Cyanocobalamin cannot be made by plants or by animals, as the only type of organisms that have the enzymes required for the synthesis of cyanocobalamin are bacteria and archaea. Higher plants do not concentrate cyanocobalamin from the soil and so are a poor source of the substance as compared with animal tissues. Cyanocobalamin is naturally found in foods including meat (especially liver and shellfish), eggs, and milk products. [HMDB]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C63H89CoN14O14P
Phân tử khối
1356.3731
Monoisotopic mass
1355.575230332
InChI
InChI=1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+1/p-1/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;/m1../s1
InChI Key
InChIKey=SEKGMJVHSBBHRD-WZHZPDAFSA-M
SMILES
OC[C@H]1O[C@@H]([C@H](O)[C@@H]1OP(O)(=O)O[C@]([H])(C)CNC(=O)CC[C@]1(C)[C@@H](CC(=O)N)[C@@]2([H])N([Co]C#N)\C1=C(C)/C1=N/C(=C\C3=N\C(=C(C)/C4=N[C@]2(C)[C@@](C)(CC(=O)N)[C@@H]4CCC(=O)N)\[C@@](C)(CC(=O)N)[C@@H]3CCC(=O)N)/C(C)(C)[C@@H]1CCC(=O)N)N1C=NC2=CC(C)=C(C)C=C12
Độ tan chảy
> 300 °C
Độ hòa tan
1.25E+004 mg/L
logP
1.87
logS
-4.5
pKa (strongest acidic)
1.84
pKa (Strongest Basic)
8.77
Physiological Charge
2
Number of Rings
8
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Cyanocobalamin (Vitamin B12) is a water-soluble organometallic compound with a trivalent cobalt ion bound inside a corrin ring. It is needed for nerve cells and red blood cells, and to make DNA. Vitamin B12 deficiency is the cause of several forms of anemia.
Cơ Chế Tác Dụng : Cyanocobalamin (commonly known as Vitamin B12) is the most chemically complex of all the vitamins. Cyanocobalamin's structure is based on a corrin ring, which, although similar to the porphyrin ring found in heme, chlorophyll, and cytochrome, has two of the pyrrole rings directly bonded. The central metal ion is Co (cobalt). Cyanocobalamin cannot be made by plants or by animals, as the only type of organisms that have the enzymes required for the synthesis of cyanocobalamin are bacteria and archaea. Higher plants do not concentrate cyanocobalamin from the soil and so are a poor source of the substance as compared with animal tissues. Cyanocobalamin is naturally found in foods including meat (especially liver and shellfish), eggs, and milk products. [HMDB] Vitamin B12 is used in the body in two forms: Methylcobalamin and 5-deoxyadenosyl cobalamin. The enzyme methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation. 5-Deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts L-methylmalonyl-CoA to succinyl-CoA. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl CoA is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells.
Dược Động Học :
▧ Absorption :
Readily absorbed in the lower half of the ileum.
▧ Protein binding :
Very high (to specific plasma proteins called transcobalamins); binding of hydroxocobalamin is slightly higher than cyanocobalamin.
▧ Metabolism :
Hepatic
▧ Half Life :
Approximately 6 days (400 days in the liver).
Độc Tính : Anaphylactic reaction (skin rash, itching, wheezing)-after parenteral administration. ORL-MUS LD50 > 8000 mg/kg
Chỉ Định : For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency.
Liều Lượng & Cách Dùng : Capsule - Oral
Liquid - Intramuscular
Liquid - Oral
Powder - Oral
Solution - Intramuscular
Tablet - Oral
Tablet, extended release - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Teva
    Sản phẩm biệt dược : Bedodeka
  • Công ty :
    Sản phẩm biệt dược : Bedoz
  • Công ty : Upjohn
    Sản phẩm biệt dược : Berubigen
  • Công ty : Lilly
    Sản phẩm biệt dược : Betalin
  • Công ty : MSD
    Sản phẩm biệt dược : Cobione
  • Công ty :
    Sản phẩm biệt dược : Cobolin-M
  • Công ty :
    Sản phẩm biệt dược : Crystamine
  • Công ty :
    Sản phẩm biệt dược : Cyanoject
  • Công ty :
    Sản phẩm biệt dược : Cyomin
  • Công ty : GlaxoSmithKline
    Sản phẩm biệt dược : Cytakon
  • Công ty : GlaxoSmithKline
    Sản phẩm biệt dược : Cytamen
  • Công ty :
    Sản phẩm biệt dược : Dicopac
  • Công ty :
    Sản phẩm biệt dược : Nascobal
  • Công ty :
    Sản phẩm biệt dược : Neuroforte-R
  • Công ty :
    Sản phẩm biệt dược : Primabalt
  • Công ty :
    Sản phẩm biệt dược : Rubramin PC
  • Công ty :
    Sản phẩm biệt dược : Vitabee 12
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00115
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=44176380
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46509031
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C02823
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00166
ChemSpider
http://www.chemspider.com/Chemical-Structure.4575342.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0270-0519-16
PharmGKB
http://www.pharmgkb.org/drug/PA451892
Wikipedia
http://en.wikipedia.org/wiki/Cyanocobalamin
RxList
http://www.rxlist.com/cgi/generic/b12inj.htm
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/vit_0262.shtml
Drugs.com
http://www.drugs.com/cdi/cyanocobalamin-b12.html
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