Tìm theo
CTI-01
Thuốc Gốc
Small Molecule
CTHH: C5H8O3
PTK: 116.1152
CTI-01 (ethyl pyruvate) is a novel anti-inflammatory agent for the treatment of critical inflammatory conditions. CTI-01 shows a potent anti-inflammatory and tissue protection activity in multiple animal models of disease including pancreatitis, ischemia-reperfusion injury, sepsis, renal injury and endotoxemia.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H8O3
Phân tử khối
116.1152
Monoisotopic mass
116.047344122
InChI
InChI=1S/C5H8O3/c1-3-8-5(7)4(2)6/h3H2,1-2H3
InChI Key
InChIKey=XXRCUYVCPSWGCC-UHFFFAOYSA-N
IUPAC Name
ethyl 2-oxopropanoate
Traditional IUPAC Name
ethyl 2-oxopropanoate
SMILES
CCOC(=O)C(C)=O
Độ hòa tan
3.13e+01 g/l
logP
0.8
logS
-0.57
pKa (strongest acidic)
16.9
pKa (Strongest Basic)
-7.7
PSA
43.37 Å2
Refractivity
27.51 m3·mol-1
Polarizability
11.39 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Cơ Chế Tác Dụng : CTI-01 (ethyl pyruvate) is a novel anti-inflammatory agent for the treatment of critical inflammatory conditions. CTI-01 shows a potent anti-inflammatory and tissue protection activity in multiple animal models of disease including pancreatitis, ischemia-reperfusion injury, sepsis, renal injury and endotoxemia. CTI-01 inhibits the systemic release of cytokines, such as TNF-alpha and HMGB1, which promote the body's inflammatory response. The over-expression of these cytokines has been linked to diseases that occur in critical care settings, such as severe organ damage following cardiopulmonary bypass (CPB) and post-operative ileus following abdominal surgery.
Chỉ Định : Investigated for use/treatment in burns and burn infections, cardiac surgery, inflammatory disorders (unspecified), ischemic reperfusion injury, and sepsis and septicemia.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05869
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=12041
ChemSpider
http://www.chemspider.com/Chemical-Structure.11544.html
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