Tìm theo
Crotamiton
Các tên gọi khác (1) :
  • Eurax
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 483-63-6
ĐG : Contract Pharm , http://www.contractpharma.com
CTHH: C13H17NO
PTK: 203.2802
Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. It is a colorless to slightly yellowish oil, having a faint amine-like odor. It is miscible with alcohol and with methanol.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C13H17NO
Phân tử khối
203.2802
Monoisotopic mass
203.131014171
InChI
InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+
InChI Key
InChIKey=DNTGGZPQPQTDQF-XBXARRHUSA-N
IUPAC Name
N-ethyl-N-(2-methylphenyl)but-2-enamide
Traditional IUPAC Name
crotamiton
SMILES
CCN(C(=O)C=CC)C1=CC=CC=C1C
Độ tan chảy
< 25 °C
Độ sôi
154 °C at 1.30E+01 mm Hg
Độ hòa tan
3.53e-01 g/l
logP
2.9
logS
-2.8
pKa (Strongest Basic)
-0.6
PSA
20.31 Å2
Refractivity
64.15 m3·mol-1
Polarizability
23.07 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Crotamiton is usually used to treat pruritis (itching of the skin) caused by scabies or sunburn. Crotamiton relieves itching by producing what is called a counter-irritation. As crotamiton evaporates from the skin, it produces a cooling effect. This cooling effect helps to divert your body's attention away from the itching. Due to this cooling effect it is also effective for the relief of sunburn. The drug is also believed to kill scabies through an unknown mechanism.
Cơ Chế Tác Dụng : Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. It is a colorless to slightly yellowish oil, having a faint amine-like odor. It is miscible with alcohol and with methanol. Crotamiton is an antiparasitic that is toxic to the scabies mite. Crotamiton also relieves itching by producing what is called a counter-irritation. As crotamiton evaporates from the skin, it produces a cooling effect. This cooling effect helps to divert your body's attention away from the itching.
Dược Động Học :
▧ Absorption :
10 % absorbed when applied locally.
Chỉ Định : For eradication of scabies (Sarcoptes scabiei) and for symptomatic treatment of pruritic skin.
Liều Lượng & Cách Dùng : Cream - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00265
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=688020
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508599
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01381
ChemSpider
http://www.chemspider.com/Chemical-Structure.2780.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0072-2103-60
PharmGKB
http://www.pharmgkb.org/drug/PA164745460
Wikipedia
http://en.wikipedia.org/wiki/Crotamiton
RxList
http://www.rxlist.com/cgi/generic3/crotamiton.htm
Drugs.com
http://www.drugs.com/cdi/crotamiton-cream.html
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