Tìm theo
Creatine
Các tên gọi khác (14 ) :
  • ((amino(Imino)methyl)(methyl)amino)acetic acid
  • (alpha-Methylguanido)acetic acid
  • (N-methylcarbamimidamido)acetic acid
  • (α-methylguanido)acetic acid
  • alpha-Methylguanidino acetic acid
  • Creatin
  • Creatine
  • Kreatin
  • Methylglycocyamine
  • N-(aminoiminomethyl)-N-methylglycine
  • N-[(e)-AMINO(imino)methyl]-N-methylglycine
  • N-Amidinosarcosine
  • N-Carbamimidoyl-N-methylglycine
  • N-Methyl-N-guanylglycine
dietary supplements, micronutrients, supplements
Thuốc Gốc
Small Molecule
CAS: 57-00-1
ATC: C01EB06
ĐG : National Vitamin Company , http://www.nationalvitamin.com
CTHH: C4H9N3O2
PTK: 131.1332
An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as creatinine in the urine. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C4H9N3O2
Phân tử khối
131.1332
Monoisotopic mass
131.069476547
InChI
InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)
InChI Key
InChIKey=CVSVTCORWBXHQV-UHFFFAOYSA-N
IUPAC Name
2-(1-methylcarbamimidamido)acetic acid
Traditional IUPAC Name
creatine
SMILES
CN(CC(O)=O)C(N)=N
Độ tan chảy
255 dec °C
Độ hòa tan
1.33E+004 mg/L (at 18 °C)
logP
-0.2
logS
-1.5
pKa (strongest acidic)
3.5
pKa (Strongest Basic)
12.43
PSA
90.41 Å2
Refractivity
42.01 m3·mol-1
Polarizability
12.17 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
5
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Creatine is a essential, non-proteinaceous amino acid found in all animals and, in some plants. Creatine is synthesized in the kidney, liver and pancreas from L-arginine, glycine and L-methionine. Following its biosynthesis, creatine is transported to the skeletal muscle, heart, brain and other tissues. Most of the creatine is metabolized in these tissues to phosphocreatine (creatine phosphate). Phosphocreatine is a major energy storage form in the body. Supplemental creatine may have an energy-generating action during anaerobic exercise and may also have neuroprotective and cardioprotective actions.
Cơ Chế Tác Dụng : An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as creatinine in the urine. [PubChem] In the muscles, a fraction of the total creatine binds to phosphate - forming creatine phosphate. The reaction is catalysed by creatine kinase, and the result is phosphocreatine (PCr). Phosphocreatine binds with adenosine diphosphate to convert it back to ATP (adenosine triphosphate), an important cellular energy source for short term ATP needs prior to oxidative phosphorylation.
Dược Động Học :

▧ Half Life :
3 hours
Chỉ Định : For nutritional supplementation, also for treating dietary shortage or imbalance
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00148
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=586
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504868
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00300
ChemSpider
http://www.chemspider.com/Chemical-Structure.566.html
PharmGKB
http://www.pharmgkb.org/drug/PA164778930
Wikipedia
http://en.wikipedia.org/wiki/Creatine
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/cre_0086.shtml
Drugs.com
http://www.drugs.com/creatine.html
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