Tìm theo
Cosyntropin
Các tên gọi khác (10 ) :
  • Adrenocorticotropic hormone 1-24
  • alpha(1-24)-Corticotrophin
  • ATCH (1-24)
  • beta(1-24)-Corticotrophin
  • Corticotropin-(1-24)
  • Corticotropin-(1-24) tetracosapeptide
  • Cosyntropin
  • SerTyrSerMetGluHisPheArgTrpGlyLysProValGlyLysLysArgArgProValLysValTyrPro
  • SYSMEHFRWGKPVGKKRRPVKVYP
  • Tetracosactide
Thuốc dùng chẩn đoán
Thuốc Gốc
Biotech
CAS: 16960-16-0
ATC: H01AA02
ĐG : Amphastar Pharmaceuticals , http://www.amphastar.com
CTHH: C136H210N40O31S
PTK: 2933.4370
A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C136H210N40O31S
Phân tử khối
2933.4370
Dược Lực Học : Cosyntropin exhibits the full corticosteroidogenic activity of natural ACTH. Various studies have shown that the biologic activity of ACTH resides in the N- terminal portion of the molecule and that the 1-20 amino acid residue is the minimal sequence retaining full activity. Partial or complete loss of activity is noted with progressive shortening of the chain beyond 20 amino acid residue. For example, the decrement from 20 to 19 results in a 70% loss of potency. The pharmacologic profile of Cosyntropin is similar to that of purified natural ACTH. It has been established that 0.25 mg of Cosyntropin will stimulate the adrenal cortex maximally and to the same extent as 25 units of natural ACTH. Cosyntropin has less immunogenic activity than ACTH because the amino acid sequence having most of the antigenic activity of ACTH, i.e., amino acids 25-39, is not present in cosyntropin. The extra-adrenal effects which natural ACTH and Cosyntropin have in common include increased melanotropic activity, increased growth hormone secretion and an adipokinetic effect. These are considered to be without physiological or clinical significance.
Cơ Chế Tác Dụng : A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. Cosyntropin combines with a specific receptor in the adrenal cell plasma membrane and, in patients with normal adrenocortical function, stimulates the initial reaction involved in the synthesis of adrenal steroids (including cortisol, cortisone, weak androgenic substances, and a limited quantity of aldosterone) from cholesterol by increasing the quantity of the substrate within the mitochondria. Cosyntropin does not significantly increase plasma cortisol concentration in patients with primary or secondary adrenocortical insufficiency.
Dược Động Học :
▧ Absorption :
Rapidly absorbed following intramuscular administration.
▧ Half Life :
About 15 minutes following intravenous administration.
Chỉ Định : For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.
Liều Lượng & Cách Dùng : Liquid - Intramuscular
Powder, for solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Cortrosyn
  • Công ty :
    Sản phẩm biệt dược : Synacthen depot
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01284
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06926
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00284
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0781-3052-95
PharmGKB
http://www.pharmgkb.org/drug/PA164749052
Wikipedia
http://en.wikipedia.org/wiki/Cosyntropin
RxList
http://www.rxlist.com/cgi/generic/cortrosyn.htm
Drugs.com
http://www.drugs.com/cdi/cosyntropin.html
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