Tìm theo
Collagenase
Các tên gọi khác (1) :
  • AA4500
Thuốc Gốc
Biotech
CAS: 9001-12-1
ATC: D03BA02
ĐG : Abbott Laboratories Ltd. , http://www.abbott.com
CTHH: C5028H7666N1300O1564S21
PTK: 112023.2000
The enzyme collagenase is derived from fermentation of Clostridium histolyticum
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5028H7666N1300O1564S21
Phân tử khối
112023.2000
Độ kỵ nước
-0.714
Điểm đẳng điện tích
5.58
Dược Lực Học : Used in the treatment of skin ulcers and sever burns, collagenase is able to digest collagen in necrotic tissue at physiological pH by hydrolyzing the peptide bonds of undenatured and denatured collagen. Collagenase thus contributes towards the formation of granulation tissue and subsequent epithelization of dermal ulcers and severely burned areas. The action of collagenase may remove substrates necessary for bacterial proliferation or may permit antibodies, leukocytes, and antibiotics better access to the infected area.
Cơ Chế Tác Dụng : The enzyme collagenase is derived from fermentation of Clostridium histolyticum Collagenase is a protease that is specific to collagen. The triple helical region of interstitial collagens is highly resistant to most cell proteinases. However, during remodeling of the connective tissue in such processes as wound healing and metastasis, collagen becomes susceptible to cleavage by collagenases. Collagenase cleaves all 3 alpha helical chains of native Types I, II and III collagens at a single locus by hydrolyzing the peptide bond following the Gly residue of the sequence: Gly 775-(Ile or Leu) 776-(Ala or Leu) 777 located approximately three-fourths of the chain length from each N-terminus
Chỉ Định : Used to promote debridement of necrotic tissue in the treatment of severe burns and dermal ulcers including decubitus ulcers.
Tương Tác Thuốc :
  • Eptifibatide Monitor therapy due to increased adverse effects of collagenase including risk of injection site bruising or bleeding.
Liều Lượng & Cách Dùng : Ointment - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Cordase
  • Sản phẩm biệt dược : Santyl
  • Công ty : Auxilium
    Sản phẩm biệt dược : Xiaflex
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00048
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00816
PharmGKB
http://www.pharmgkb.org/drug/PA449107
Wikipedia
http://en.wikipedia.org/wiki/Collagenase
RxList
http://www.rxlist.com/cgi/generic3/collagenase.htm
Drugs.com
http://www.drugs.com/cdi/collagenase-ointment.html
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