Tìm theo
Coagulation factor VIIa
Các tên gọi khác (5 ) :
  • Coagulation factor VII precursor
  • Eptacog alfa
  • Proconvertin
  • Serum prothrombin conversion accelerator
  • SPCA
coagulants, thrombotic agents
Thuốc Gốc
Biotech
CAS: 9001-25-6
ĐG : Novo Nordisk Inc. , http://www.novonordisk.com
CTHH: C1972H3076N560O597S28
PTK: 45079.1000
Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade.1 NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C1972H3076N560O597S28
Phân tử khối
45079.1000
Độ tan chảy
58 °C
Độ kỵ nước
-0.311
Điểm đẳng điện tích
6.09
Dược Lực Học : Used in the treatment of bleeding episodes in hemophilia A or B. NovoSeven is recombinant Factor VIIa and, when complexed with tissue factor can activate coagulation Factor X to Factor Xa, as well as coagulation Factor IX to Factor IXa. Factor Xa, in complex with other factors, then converts prothrombin to thrombin, which leads to the formation of a hemostatic plug by converting fibrinogen to fibrin and thereby inducing local clotting.
Cơ Chế Tác Dụng : Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade.1 NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form. NovoSeven activates the coagulation or clotting cascade by cleaving Factor IX and Factor X, which activates them and then leads to activation of thrombin and fibrin.
Dược Động Học :

▧ Volume of Distribution :
* 121 ± 30 mL/kg [adults] * 153 ± 29 mL/kg [children] * 280 to 290 mL/kg [congenital Factor VII deficiency]
▧ Clearance :
* 33 - 37 mL/h x kg [healthy] * 1375 +/- 396 mL/hr [severe hemophilia A male children] * 57.3 +/- 9.5 mL/hr/kg [severe hemophilia A male children] * 2767 +/- 385 mL/hr [severe hemophilia A men] * 37.6 +/- 13.1 mL/hr/kg [severe hemophilia A men]
Chỉ Định : For treatment of hemorrhagic complications in hemophilia A and B
Liều Lượng & Cách Dùng : Injection, powder, lyophilized, for solution - Intravenous bolus
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Novo Nordisk
    Sản phẩm biệt dược : NovoSeven
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00036
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C03378
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00172
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0169-7010-01
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/M13232
PharmGKB
http://www.pharmgkb.org/drug/PA164748389
Wikipedia
http://en.wikipedia.org/wiki/Factor_VII
RxList
http://www.rxlist.com/cgi/generic3/novoseven.htm
Drugs.com
http://www.drugs.com/cdi/coagulation-factor-viia-recombinant.html
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