Tìm theo
Coagulation Factor IX
Các tên gọi khác (4 ) :
  • Christmas factor
  • Coagulation factor IX precursor
  • Plasma thromboplastin component
  • PTC
coagulants, thrombotic agents
Thuốc Gốc
Biotech
CAS: 9001-28-9
ATC: B02BD04
ĐG : CSL Behring LLC , http://www.cslbehring.com
CTHH: C2041H3136N558O641S25
PTK: 46548.2000
Human Factor IX protein, produced by recombinant DNA technology for use in therapy of factor IX deficiency, known as hemophilia B or Christmas disease. Coagulation Factor IX (Recombinant) is a glycoprotein with an approximate molecular mass of 55,000 Da consisting of 415 amino acids in a single chain. It has a primary amino acid sequence that is identical to the Ala 148 allelic form of plasma-derived factor IX.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C2041H3136N558O641S25
Phân tử khối
46548.2000
Độ tan chảy
54 °C
Độ kỵ nước
-0.431
Điểm đẳng điện tích
5.20
Dược Lực Học : Binds vitamin K and factor VIIIa. Cleaves the Arg-Ile bond in factor X to form active factor Xa. Plays a key role in blood coagulation and clotting. Injections of factor IX are used to treat hemophilia B, which is sometimes called Christmas disease. AlphaNine is injected to increase plasma levels of Factor IX and can temporarily correct this coagulation defect.
Cơ Chế Tác Dụng : Human Factor IX protein, produced by recombinant DNA technology for use in therapy of factor IX deficiency, known as hemophilia B or Christmas disease. Coagulation Factor IX (Recombinant) is a glycoprotein with an approximate molecular mass of 55,000 Da consisting of 415 amino acids in a single chain. It has a primary amino acid sequence that is identical to the Ala 148 allelic form of plasma-derived factor IX. Coagulation Factor IX is an important protein in the process of hemostasis and normal blood clotting. Factor IX is plays an important intermediate role in the blood coagulation cascade. It is located within the blood plasma as a zymogen, an antecedent to enzymatic function, in its inactivated state. Factor IX is dependent on the presence of Vitamin K, and is activated to a serine protease by the function of Coagulation Factor XIa. Factor XIa cleaves the peptide bond associated with protein activation in Factor IX, leaving Factor IX with two exposed chains, a light chain and a heavy chain. These two chains are held together by several disulfide bonds that reinforce the structure of Factor IX's activated form. After being activated, Factor IX forms a complex with calcium ions, membrane phospholipids and Coagulation Factor VIII to activate Coagulation Factor X. The activation of Factor X then performs a similarly integral step in the blood coagulation cascade. The ultimate result of phenotypically normal coagulation factors is the creation of platelets for normal blood clotting.
Dược Động Học :

▧ Half Life :
19.4 ± 5.4 hours (range from 11 to 36 hours)
Chỉ Định : For treatment of hemophilia (Christmas disease).
Liều Lượng & Cách Dùng : Injection, powder, lyophilized, for solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00100
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C03101
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0053-7668-02
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/K02402
PharmGKB
http://www.pharmgkb.org/drug/PA164744952
Wikipedia
http://en.wikipedia.org/wiki/Factor_IX
RxList
http://www.rxlist.com/cgi/generic2/factorix.htm
Drugs.com
http://www.drugs.com/cdi/coagulation-factor-ix-injection-human.html
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