Tìm theo
Cloxacillin
Các tên gọi khác (7 ) :
  • (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • (3-(O-Chlorophenyl)-5-methyl-4-isoxazolyl)penicillin
  • 6-(3-(O-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid
  • Cloxacilina
  • CLOXACILLIN
  • Cloxacilline
  • Cloxacillinum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 61-72-3
ĐG : Apothecon , http://www.apothecon.nl
CTHH: C19H18ClN3O5S
PTK: 435.881
A semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H18ClN3O5S
Phân tử khối
435.881
Monoisotopic mass
435.065569098
InChI
InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1
InChI Key
InChIKey=LQOLIRLGBULYKD-JKIFEVAISA-N
IUPAC Name
(2S,5R,6R)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Traditional IUPAC Name
oxacillin
SMILES
[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl)C(O)=O
Độ hòa tan
13.9 mg/L
logP
2.48
logS
-3.9
pKa (strongest acidic)
3.75
pKa (Strongest Basic)
-0.41
PSA
112.74 Å2
Refractivity
106.64 m3·mol-1
Polarizability
41.64 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
5
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
2.78
Dược Lực Học : Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is for use against staphylococci that produce beta-lactamase.
Cơ Chế Tác Dụng : A semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. [PubChem] By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cloxacillin interferes with an autolysin inhibitor.
Dược Động Học :
▧ Absorption :
Well absorbed from the gastrointestinal tract.
▧ Protein binding :
95%
Độc Tính : Oral LD50 in rat and mouse is 5000 mg/kg. Intravenous LD50 in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.
Chỉ Định : Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci.
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Capsule - Oral
Powder, for solution - Intramuscular
Powder, for solution - Intravenous
Powder, for solution - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Southshourne
    Sản phẩm biệt dược : Aclox
  • Công ty : Apotex
    Sản phẩm biệt dược : Apo-Cloxi
  • Công ty : Cirin
    Sản phẩm biệt dược : Auropen Inj.
  • Công ty : Saiph
    Sản phẩm biệt dược : Cloxacil
  • Công ty : MacroPhar
    Sản phẩm biệt dược : Cloxam
  • Công ty : GlaxoSmithKline
    Sản phẩm biệt dược : Orbenin
  • Công ty : Atlantic
    Sản phẩm biệt dược : Vaclox
  • Công ty : Vamsler
    Sản phẩm biệt dược : Vamcloxil
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01147
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6098
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507109
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06923
ChemSpider
http://www.chemspider.com/Chemical-Structure.5873.html
PharmGKB
http://www.pharmgkb.org/drug/PA449059
Wikipedia
http://en.wikipedia.org/wiki/Cloxacillin
Drugs.com
http://www.drugs.com/mtm/cloxacillin.html
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