Tìm theo
Clomocycline
Các tên gọi khác (4 ) :
  • Chlormethylenecycline
  • Clomociclina
  • Clomocyclina
  • Clomocyclinum
tetracyclines
Thuốc Gốc
Small Molecule
CAS: 1181-54-0
ATC: J01AA11
CTHH: C23H25ClN2O9
PTK: 508.906
Clomocycline is a tetracycline antibiotic.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H25ClN2O9
Phân tử khối
508.906
Monoisotopic mass
508.124858115
InChI
InChI=1S/C23H25ClN2O9/c1-22(34)8-6-9-16(26(2)3)18(30)14(21(33)25-7-27)20(32)23(9,35)19(31)12(8)17(29)13-11(28)5-4-10(24)15(13)22/h4-5,8-9,16,27-28,30-31,34-35H,6-7H2,1-3H3,(H,25,33)/t8-,9-,16-,22-,23-/m0/s1
InChI Key
InChIKey=GJGDLRSSCNAKGL-KMVLDZISSA-N
IUPAC Name
(4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-N-(hydroxymethyl)-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
Traditional IUPAC Name
clomocycline
SMILES
[H][C@@]12C[C@@]3([H])C(=C(O)[C@]1(O)C(=O)C(C(=O)NCO)=C(O)[C@H]2N(C)C)C(=O)C1=C(O)C=CC(Cl)=C1[C@@]3(C)O
Độ hòa tan
1.77e+00 g/l
logP
0.2
logS
-2.5
pKa (strongest acidic)
0.013
pKa (Strongest Basic)
8.23
PSA
187.86 Å2
Refractivity
124.99 m3·mol-1
Polarizability
49.29 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
10
H Bond Donor Count
7
Physiological Charge
-1
Number of Rings
4
Bioavailability
0
Dược Lực Học : Clomocycline is a tetracycline antibiotic that is commonly prescribed by medical doctors for infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Clomocycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease. Clomocycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Cells become resistant to Clomocycline by at least two mechanisms: efflux and ribosomal protection. In efflux, a resistance gene encodes a membrane protein that actively pumps Clomocycline out of the cell. This is the mechanism of action of the tetracycline resistance gene on the artificial plasmid pBR322. In ribosomal protection, a resistance gene encodes a protein which binds to the ribosome and prevents Clomocycline from acting on the ribosome.
Cơ Chế Tác Dụng : Clomocycline is a tetracycline antibiotic. Clomocycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Clomocycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.
Chỉ Định : For the treatment and management of Brucellosis, mycoplasma infection, acne vulgaris, chlamydial infection;Chronic bronchitis
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00453
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5464321
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505301
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D06885
ChemSpider
http://www.chemspider.com/Chemical-Structure.4576619.html
PharmGKB
http://www.pharmgkb.org/drug/PA164771235
Wikipedia
http://en.wikipedia.org/wiki/Clomocycline
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