Tìm theo
Clobutinol
Thuốc Gốc
Small Molecule
CAS: 14860-49-2
CTHH: C14H22ClNO
PTK: 255.784
Clobutinol is a cough suppressant that is withdrawn from the US and EU markets. Studies in 2004 had indicated that clobutinol has the potential to prolong the QT interval. In 2007, Clobutinol was determined to cause cardiac arrhythmia in some patients.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H22ClNO
Phân tử khối
255.784
Monoisotopic mass
255.138992038
InChI
InChI=1/C14H22ClNO/c1-11(10-16(3)4)14(2,17)9-12-5-7-13(15)8-6-12/h5-8,11,17H,9-10H2,1-4H3
InChI Key
InChIKey=KVHHQGIIZCJATJ-UHFFFAOYNA-N
IUPAC Name
1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol
Traditional IUPAC Name
iversal
SMILES
CC(CN(C)C)C(C)(O)CC1=CC=C(Cl)C=C1
Độ sôi
145-148
Độ hòa tan
5.35e-01 g/l
logP
3
logS
-2.7
pKa (strongest acidic)
14.64
pKa (Strongest Basic)
9.41
PSA
23.47 Å2
Refractivity
74.04 m3·mol-1
Polarizability
28.85 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB09004
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07716
Wikipedia
http://en.wikipedia.org/wiki/Clobutinol
Drugs.com
http://www.drugs.com/international/clobutinol.html
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