Tìm theo
Clioquinol
Các tên gọi khác (13 ) :
  • 5-Chlor-7-jod-8-hydroxy-chinolin
  • 5-Chloro-7-iodo-8-hydroxyquinoline
  • 5-Chloro-7-iodo-8-quinolinol
  • 5-chloro-7-iodoquinolin-8-ol
  • 5-Chloro-8-hydroxy-7-iodoquinoline
  • 7-Iodo-5-chloro-8-hydroxyquinoline
  • 7-Iodo-5-chloroxine
  • Chloroiodoquin
  • Clioquinolum
  • Iodochlorhydroxyquin
  • Iodochlorhydroxyquinoline
  • Iodochlorohydroxyquin
  • Iodochloroxyquinoline
Thuốc Gốc
Small Molecule
CAS: 130-26-7
ATC: P01AA02, D08AH30, S02AA05, G01AC02, D09AA10
CTHH: C9H5ClINO
PTK: 305.5
Clioquinol was withdrawn in 1983 due to neurotoxicity.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H5ClINO
Phân tử khối
305.5
Monoisotopic mass
304.910434914
InChI
InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
InChI Key
InChIKey=QCDFBFJGMNKBDO-UHFFFAOYSA-N
IUPAC Name
5-chloro-7-iodoquinolin-8-ol
Traditional IUPAC Name
clioquinol
SMILES
OC1=C(I)C=C(Cl)C2=C1N=CC=C2
Độ tan chảy
178.5 °C
Độ hòa tan
2.64e-01 g/l
logP
3.36
logS
-3.1
pKa (strongest acidic)
7.34
pKa (Strongest Basic)
3.28
PSA
33.12 Å2
Refractivity
60.13 m3·mol-1
Polarizability
22.63 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Dược Lực Học : Clioquinol is a broad-spectrum antibacterial with antifungal properties. Application of clioquinol to extensive or eroded areas of the skin may lead to increased protein-bound iodine (PBI) levels within 1 week. In addition, elevated PBI levels may occur when relatively small areas of the skin are treated with clioquinol for more than 1 week.
Cơ Chế Tác Dụng : Clioquinol was withdrawn in 1983 due to neurotoxicity. Clioquinol is bacteriostatic, however, the precise mechanism of its action is unknown.
Dược Động Học :
▧ Absorption :
Topical absorption is rapid and extensive, especially when the skin is covered with an occlusive dressing or if the medication is applied to extensive or eroded areas of the skin. Clioquinol is absorbed through the skin in sufficient amounts to affect thyroid function tests.
Chỉ Định : Used as a topical antifungal treatment.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04815
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2788
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46509081
ChemSpider
http://www.chemspider.com/Chemical-Structure.2686.html
PharmGKB
http://www.pharmgkb.org/drug/PA449039
Wikipedia
http://en.wikipedia.org/wiki/Clioquinol
Drugs.com
http://www.drugs.com/mtm/clioquinol-topical.html
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