Tìm theo
Clidinium
Các tên gọi khác (8 ) :
  • 3-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-methyl-1-azonia-bicyclo[2.2.2]octane
  • 3-Hydroxy-1-methylquinuclidinium benzilate ester
  • Bromure de Clidinium
  • Bromuro de clidinio
  • Clidinii Bromidum
  • CLIDINIUM
  • Clidinium bromid
  • N-Methyl quinuclidinyl benzilate
Thuốc chống loạn nhịp
Thuốc Gốc
Small Molecule
CAS: 7020-55-5
ĐG : Avkare Incorporated
CTHH: C22H26NO3
PTK: 352.4467
Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H26NO3
Phân tử khối
352.4467
Monoisotopic mass
352.191268703
InChI
InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1/t17-,20?,23+
InChI Key
InChIKey=HOOSGZJRQIVJSZ-NNBUQUNQSA-N
IUPAC Name
(1s,4s)-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-1-azabicyclo[2.2.2]octan-1-ium
Traditional IUPAC Name
clidinium
SMILES
C[N@@+]12CC[C@@H](CC1)C(C2)OC(=O)C(O)(C1=CC=CC=C1)C1=CC=CC=C1
Độ tan chảy
240-241 °C
Độ hòa tan
3.77e-04 g/l
logP
-1.1
logS
-6
pKa (strongest acidic)
11.05
pKa (Strongest Basic)
-4.5
PSA
46.53 Å2
Refractivity
112.14 m3·mol-1
Polarizability
38.76 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
4
Bioavailability
1
Rule of Five
true
Dược Lực Học : Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract.
Cơ Chế Tác Dụng : Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome. Inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites primarily by inhibiting the M1 muscarinic receptors.
Độc Tính : Signs of toxicity include confusion, paralytic ileus, urinary hesitancy/retention, and blurred vision.
Chỉ Định : For the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.
Tương Tác Thuốc :
  • Donepezil Possible antagonism of action
  • Galantamine Possible antagonism of action
  • Haloperidol The anticholinergic increases the risk of psychosis and tardive dyskinesia
  • Potassium Chloride Anticholinergic agents such as clidinium may enhance the ulcerogenic effect of potassium chloride. Solid oral dosage forms of potassium chloride are contraindicated in patients with impaired gastric emptying (e.g., due to the effects of drugs such as many anticholinergics). Patients on drugs with substantial anticholinergic effects should avoid using any solid oral dosage form of potassium chloride; liquid or effervescent potassium preparations are possible alternatives.
  • Pramlintide Pramlintide may enhance the anticholinergic effect of anticholinergics such as clidinium. These effects are specific to the GI tract. Use caution during concomitant therapy with pramlintide and anticholinergics. Additive effects on reduced GI motility may occur.
  • Secretin Anticholinergic agents such as secretin may diminish the stimulatory effect of secretin. Avoid using drugs with substantial anticholinergic effects in patients receiving secretin whenever possible. If such agents must be used in combination, monitor response to secretin closely.
  • Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Clidinium, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
  • Trimethobenzamide Trimethobenzamide and Clidinium, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
  • Triprolidine Triprolidine and Clidinium, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
  • Trospium Trospium and Clidinium, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Quarzan 2.5 mg capsule
    Giá bán buôn : USD >0.23
    Đơn vị tính : capsule
  • Biệt dược thương mại : Quarzan 5 mg capsule
    Giá bán buôn : USD >0.3
    Đơn vị tính : capsule
Nhà Sản Xuất
  • Công ty : Roche
    Sản phẩm biệt dược : Dolibrax
  • Công ty : Roche
    Sản phẩm biệt dược : Librax
  • Công ty : Ying Yuan
    Sản phẩm biệt dược : Porsucon
  • Công ty : Roche
    Sản phẩm biệt dược : Quarzan
  • Công ty : Hua Shin
    Sản phẩm biệt dược : Sedaspa
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00771
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07853
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055977
PharmGKB
http://www.pharmgkb.org/drug/PA164781044
Wikipedia
http://en.wikipedia.org/wiki/Clidinium
Drugs.com
http://www.drugs.com/mtm/clidinium.html
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